猴病毒40型dl 54/59突变体裂解生长的可变缺陷性。
Variable defectiveness for lytic growth of the dl 54/59 mutants of simian virus 40.
作者信息
Topp W C
出版信息
J Virol. 1980 Mar;33(3):1208-10. doi: 10.1128/JVI.33.3.1208-1210.1980.
Abstract
When viral growth in TC-7 cells is compared with that in the simian virus 40 (SV40) transformed CV-1 line C6 some mutants of SV40 deleted between 0.54 and 0.59 on the standard map (dl 54/59 mutants) give relative bursts similar to those of wild-type strain 776, whereas others grow markedly poorer in the untransformed cell. In general, viruses which are defective by this criterion have been found to produce neither a fragmentary small-t protein nor a mature small-t mRNA.
摘要
当将TC - 7细胞中的病毒生长情况与猿猴病毒40（SV40）转化的CV - 1细胞系C6中的情况进行比较时，标准图谱上0.54至0.59之间缺失的一些SV40突变体（dl 54/59突变体）产生的相对爆发量与野生型毒株776相似，而其他突变体在未转化细胞中的生长明显较差。一般来说，根据这一标准有缺陷的病毒既不产生片段化的小t蛋白，也不产生成熟的小t mRNA。
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