禽肉瘤前病毒DNA序列在非允许性XC细胞中发生修饰，而在允许性鸡细胞中则不然。
Modification of avian sarcoma proviral DNA sequences in nonpermissive XC cells but not in permissive chicken cells.
作者信息
Guntaka R V, Rao P Y, Mitsialis S A, Katz R
出版信息
J Virol. 1980 May;34(2):569-72. doi: 10.1128/JVI.34.2.569-572.1980.
Abstract
For the first time, we present evidence with restriction enzymes HpaII and MspI which indicates that the proviral DNA sequence of avian sarcoma virus is modified by methylation in a nonpermissive rat cell line but not in permissive chicken cells. Some of the endogenous viral sequences in the permissive cells were also methylated. No 5-methylcytosine could be detected in the unintegrated viral DNA.
摘要
我们首次用限制性内切酶HpaII和MspI提供了证据，表明禽肉瘤病毒的前病毒DNA序列在非允许性大鼠细胞系中会因甲基化而发生修饰，但在允许性鸡细胞中则不会。允许性细胞中的一些内源性病毒序列也发生了甲基化。在未整合的病毒DNA中未检测到5-甲基胞嘧啶。
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