Diosi P, Plavoşin L, Herzog G
Rev Ig Bacteriol Virusol Parazitol Epidemiol Pneumoftiziol Bacteriol Virusol Parazitol Epidemiol. 1980 Jan-Mar;25(1):1-10.
The crown-like projections on the surface of the particles permits differentiation of coronaviruses from other riboviruses and their individualization as a distinct family. Recognition of their role in the aetiology of respiratory, enteral and encephalitic infections has promoted investigations for the finding of preventive vaccines. Selection of the strains showed that their immunogenicity depends upon the density and salience of the crown-like projections, the antigenic relationship of the projections determining cross serologic reactions between different species. At present experiments are being carried out on animals with vaccines prepared with antigenically related heterologous cornavirus species, not pathogenic for the host, and with subunitary vaccines prepared from the projections of the homologous species. The Coronaviridae family established on morphologic criteria is thus confirmed by the immunologic relationship and specificity of its members.
病毒颗粒表面的冠状突起使得冠状病毒能够与其他核糖病毒区分开来，并将其作为一个独特的病毒科独立出来。认识到它们在呼吸道、肠道和脑部感染病因学中的作用，推动了寻找预防性疫苗的研究。对毒株的筛选表明，它们的免疫原性取决于冠状突起的密度和显著程度，突起的抗原关系决定了不同物种之间的交叉血清学反应。目前正在用对宿主无致病性的抗原相关异源冠状病毒株制备的疫苗以及用同源物种突起制备的亚单位疫苗在动物身上进行实验。因此，根据形态学标准建立的冠状病毒科通过其成员之间的免疫关系和特异性得到了证实。
