Miller A E
Neurology. 1980 Jun;30(6):582-7. doi: 10.1212/wnl.30.6.582.
The incidence of herpes zoster rises markedly in the aged. We evaluated the hypothesis that cellular immunity to varicella-zoster (VZ) viral antigens may be impaired in aged subjects. We found that the lymphocyte proliferation to VZ antigen was less in older asymptomatic individuals than in normal young controls. In contrast, responses to other antigens did not differ. Antibody titers to VZ were similar in both young and old subjects. Impairment of cellular immunity to VZ, on a population basis, may contribute to the increased risk of herpes zoster in the elderly.
带状疱疹的发病率在老年人中显著上升。我们评估了一个假设，即老年受试者对水痘-带状疱疹（VZ）病毒抗原的细胞免疫可能受损。我们发现，年龄较大的无症状个体对VZ抗原的淋巴细胞增殖低于正常年轻对照组。相比之下，对其他抗原的反应没有差异。年轻和老年受试者对VZ的抗体滴度相似。在总体人群中，对VZ的细胞免疫受损可能导致老年人患带状疱疹的风险增加。
