Gershon A A, Steinberg S P, Borkowsky W, Lennette D, Lennette E
Pediatr Infect Dis. 1982 May-Jun;1(3):164-7. doi: 10.1097/00006454-198205000-00007.
Antibody to varicella-zoster (VZ) virus of the IgM type was detected in sera from 50% of persons with clinical zoster, 67% of asymptomatic varicella immunes with a recent intimate exposure to VZ virus and 22 to 40% of varicella immunes with no symptoms of zoster or known exposure to the virus. No VZ IgM was found in newborn sera or in sera from persons susceptible to varicella, demonstrating specificity of the VA IgM assay. Since development of specific IgM is associated with acute infection, these data suggest that reinfection with VA virus occurs and also that antigenic stimulation due to exposure to endogenous VZ virus may occur. We hypothesize that during reactivation of VZ virus, persons with intact VZ cell-mediated immunity (CMI) remain asymptomatic but that those with depressed VZ CMI may develop clinical zoster. These data suggest that there is an unstable relationship between VZ virus and the human host.
在50%的临床带状疱疹患者血清中检测到IgM型水痘-带状疱疹（VZ）病毒抗体，67%近期有VZ病毒密切接触史的无症状水痘免疫者血清中检测到该抗体，22%至40%无带状疱疹症状或无已知病毒接触史的水痘免疫者血清中也检测到该抗体。在新生儿血清或水痘易感者血清中未发现VZ IgM，这证明了VZ IgM检测的特异性。由于特异性IgM的产生与急性感染相关，这些数据表明VZ病毒会发生再感染，并且因接触内源性VZ病毒而产生的抗原刺激也可能发生。我们推测，在VZ病毒再激活期间，VZ细胞介导免疫（CMI）完整的人仍无症状，但VZ CMI低下的人可能会发生临床带状疱疹。这些数据表明VZ病毒与人类宿主之间存在不稳定的关系。
