Sarateanu D E, Ehrengut W
Infection. 1980;8(2):70-2. doi: 10.1007/BF01639150.
The occurrence of OC-43 coronarvirus-like infections in the population of Hamburg was determined by a monthly serological survey (hemagglutintion inhibition test [HI]) undertaken between October 1974 and October 1976. Studies of 3,016 sera revealed a high incidence of HI antibodies (58,2%). The frequency of seropositive reactions (= 1:8) and the geometric mean titer were higher in individuals 15 to 24 years old. Treatment of 50 postive sera (titer 1:16 -1:64) with receptor destroying enzyme, kaolin and ethacridin for elimination of nonspecific inhbitiros did not modify the HI-titer of the investigated sera. The serological seasonal pattern suggests that coronaviruses are circulating the whole year in the urban population with a prevlence in the fall-winter period. Of the 331 paired sera examined, 6.6% presented a four- to eightfold rise intiter within eight weeks.
通过1974年10月至1976年10月期间每月进行的血清学调查（血凝抑制试验[HI]），确定了汉堡人群中OC-43冠状病毒样感染的发生情况。对3016份血清的研究显示HI抗体的高发生率（58.2%）。15至24岁个体的血清阳性反应频率（=1:8）和几何平均滴度更高。用受体破坏酶、高岭土和依沙吖啶处理50份阳性血清（滴度1:16 - 1:64）以消除非特异性抑制剂，并未改变所研究血清的HI滴度。血清学季节模式表明，冠状病毒在城市人群中全年传播，在秋冬季节更为普遍。在331对检测的血清中，6.6%在八周内滴度呈四至八倍升高。
