Rosenberg L, Slone D, Shapiro S, Kaufman D, Stolley P D, Miettinen O S
JAMA. 1980 Jul 25;244(4):339-42.
The effect of noncontraceptive estrogens on the risk of myocardial infarction (MI) in women aged 30 to 49 years was investigated in 477 women with first infarctions and in 1,832 hospital control subjects. There was little evidence of an effect: overall, the estimated relative risk of acute MI for women who had used noncontraceptive estrogens in the preceding month, after allowance for potential confounding factors, was 1.0 (95% confidence intervals, 0.6 to 1.7); the corresponding estimate for women who had discontinued use more than one month previously was 1.2 (0.8 to 1.8). There was also no apparent association in various subgroups, including women who smoked heavily and those who had no identified predisposition.
在477名首次发生心肌梗死的女性和1832名医院对照受试者中，研究了非避孕雌激素对30至49岁女性心肌梗死（MI）风险的影响。几乎没有证据表明存在影响：总体而言，在考虑潜在混杂因素后，前一个月使用过非避孕雌激素的女性发生急性心肌梗死的估计相对风险为1.0（95%置信区间为0.6至1.7）；停用超过一个月的女性的相应估计值为1.2（0.8至1.8）。在包括大量吸烟女性和无明确易患因素女性在内的各个亚组中，也没有明显的关联。
