Hagenäs L, Plöen L, Ekwall H
J Endocrinol. 1978 Jan;76(1):87-91. doi: 10.1677/joe.0.0760087.
To study the hormonal dependence of the blood-testis barrier, adult rats were hypophysectomized and the ultrastructural integrity of the inter-Sertoli cell junctional complex was examined at various times with a lanthanum tracer technique. It was found that the structural integrity of the inter-Sertoli cell junctions and their capacity to exclude lanthanum from the adluminal compartment were preserved up to 35 days after hypophysectomy. Furthermore, transport of newly formed spermatocytes through the inter-Sertoli cell junctions still occurred 20 days after hypophysectomy. It is therefore concluded that the function of the inter-Sertoli cell junctional complex is not directly dependent on gonadotrophic or androgenic hormones, but is regulated by other mechanisms.
为研究血睾屏障的激素依赖性，对成年大鼠进行垂体切除，并在不同时间用镧示踪技术检查支持细胞间连接复合体的超微结构完整性。结果发现，垂体切除后35天内，支持细胞间连接的结构完整性及其将镧排除在管腔隔室之外的能力得以保留。此外，垂体切除20天后，新形成的精母细胞仍通过支持细胞间连接进行转运。因此得出结论，支持细胞间连接复合体的功能并非直接依赖于促性腺激素或雄激素，而是由其他机制调节。
