Cameron D F, Snydle F E
Fertil Steril. 1980 Sep;34(3):255-8. doi: 10.1016/s0015-0282(16)44958-7.
Testicular biopsy specimens were obtained from 28 otherwise healthy males (22 to 37 years old) with diagnosed varicocele. Tissue was processed for ultrastructural and intercellular tracer studies using lanthanum nitrate. In all cases Sertoli-Sertoli junctional complexes appeared structurally intact and functionally normal on the basis of their ability to occlude lanthanum from the adluminal testicular compartment. Our results indicate that, even in the presence of severe dissolution of the adluminal testicular compartment as evidenced in varicocele, both the basal compartment and the blood-testis barrier remain relatively normal. In varicocele, not only does the blood-testis barrier remain effective in segregating the two testicular compartments, but it appears to act as a device that limits the progression of apical Sertoli cell cytoplasmic degeneration and seminiferous epithelial dissolution, thereby allowing a pool of progenitor germ cells to be maintained and protected in the basal compartment.
从28名确诊为精索静脉曲张的健康男性（22至37岁）获取睾丸活检标本。使用硝酸镧对组织进行处理，用于超微结构和细胞间示踪研究。在所有病例中，根据其阻止镧进入睾丸管腔隔室的能力，支持细胞-支持细胞连接复合体在结构上似乎完整且功能正常。我们的结果表明，即使在精索静脉曲张所显示的管腔隔室严重溶解的情况下，基底隔室和血睾屏障仍相对正常。在精索静脉曲张中，血睾屏障不仅在分隔两个睾丸隔室方面仍然有效，而且似乎起到了限制支持细胞顶端细胞质变性和生精上皮溶解进展的作用，从而使一群祖代生殖细胞得以在基底隔室中维持和受到保护。
