Duran-Reynals M L, Lilly F, Bosch A, Blank K J
J Exp Med. 1978 Feb 1;147(2):459-69. doi: 10.1084/jem.147.2.459.
Susceptibility to leukemia induction in mice by skin painting with 3-methylcholanthrene (MCA) is strain-specific, occurring only in strains relatively resistant to MCA-induced skin tumors. The Ah locus, which has a dominant allele (Ahb) for inducibility of the aryl hydrocarbon hydroxylase (AHH) enzyme system and a recessive allele (Ahd) for noninducibility, appears to be the major determinant of this trait. MCA-painted mice of strains and crosses carrying the Ahb allele usually show a high incidence of skin tumors (papillomas which may evolve into malignant tumors) and little or no leukemia, whereas in mice homozygous for the Ahd allele the treatment usually induces a high incidence of leukemia and few or no skin tumors. Among mice of a segregating backcross generation including both Ahb/Ahd heterozygotes and Ahd homozygotes, the occurrence of skin tumors was correlated directly with AHH inducibility and inversely with the leukemic response. Mice of Ahb strains with a high level of endogenous murine leukemia (MuLV) expression (C58, PL) show a much weaker skin tumor response than expected but no increase in leukemia incidence, and this observation tends to confirm the previous finding that MuLV infection of mice of low-MuLV strains results in reduced susceptibility to MCA tumorigenesis.
用3-甲基胆蒽（MCA）进行皮肤涂抹诱导小鼠患白血病的易感性具有品系特异性，仅发生在对MCA诱导的皮肤肿瘤相对抗性的品系中。芳烃羟化酶（AHH）酶系统诱导性的显性等位基因（Ahb）和非诱导性的隐性等位基因（Ahd）所在的Ah位点似乎是这一性状的主要决定因素。携带Ahb等位基因的品系和杂交种的MCA涂抹小鼠通常显示出高发生率的皮肤肿瘤（可能演变为恶性肿瘤的乳头状瘤）且很少或没有白血病，而在Ahd等位基因纯合的小鼠中，该处理通常诱导高发生率的白血病且很少或没有皮肤肿瘤。在包括Ahb/Ahd杂合子和Ahd纯合子的分离回交世代的小鼠中，皮肤肿瘤的发生与AHH诱导性直接相关，与白血病反应呈负相关。具有高水平内源性鼠白血病病毒（MuLV）表达的Ahb品系小鼠（C58、PL）显示出比预期弱得多的皮肤肿瘤反应，但白血病发病率没有增加，这一观察结果倾向于证实先前的发现，即低MuLV品系小鼠的MuLV感染导致对MCA肿瘤发生的易感性降低。
