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小鼠中芳烃羟化酶诱导性与化学致癌物诱发皮肤溃疡之间的遗传关系。

Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice.

作者信息

Thomas P E, Hutton J J, Taylor B A

出版信息

Genetics. 1973 Aug;74(4):655-9. doi: 10.1093/genetics/74.4.655.

DOI:10.1093/genetics/74.4.655
PMID:4750810
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1212981/
Abstract

Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are genetically controlled by alleles at the In and Ahh loci, respectively. Genetic analyses and strain surveys indicate that the In and Ahh loci are identical, or very closely linked.

摘要

在局部应用多环烃后，近交系小鼠表现出不同的皮肤炎症反应。这些品系在这些化合物诱导肝芳烃羟化酶活性的程度上也存在差异。不同的炎症反应和羟化酶诱导性分别由In和Ahh位点的等位基因进行遗传控制。遗传分析和品系调查表明，In和Ahh位点相同或紧密连锁。

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Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice.小鼠中芳烃羟化酶诱导性与化学致癌物诱发皮肤溃疡之间的遗传关系。
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本文引用的文献

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Proc Natl Acad Sci U S A. 1971 Dec;68(12):3190-4. doi: 10.1073/pnas.68.12.3190.
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Proc Natl Acad Sci U S A. 1969 Dec;64(4):1188-94. doi: 10.1073/pnas.64.4.1188.
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Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo.芳烃羟化酶诱导的遗传调控。II. 小鼠组织在体内的简单孟德尔式表达。
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In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons.多环烃K区域衍生物对啮齿动物细胞的体外转化
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