小鼠中芳烃羟化酶诱导性与化学致癌物诱发皮肤溃疡之间的遗传关系。
Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice.
作者信息
Thomas P E, Hutton J J, Taylor B A
出版信息
Genetics. 1973 Aug;74(4):655-9. doi: 10.1093/genetics/74.4.655.
Abstract
Inbred strains of mice show differential skin inflammatory reactivity following the topical application of polycyclic hydrocarbons. Strains also differ in the extent to which hepatic aryl hydrocarbon hydroxylase activity is induced by these compounds. Differential inflammatory response and hydroxylase inducibility are genetically controlled by alleles at the In and Ahh loci, respectively. Genetic analyses and strain surveys indicate that the In and Ahh loci are identical, or very closely linked.
摘要
在局部应用多环烃后，近交系小鼠表现出不同的皮肤炎症反应。这些品系在这些化合物诱导肝芳烃羟化酶活性的程度上也存在差异。不同的炎症反应和羟化酶诱导性分别由In和Ahh位点的等位基因进行遗传控制。遗传分析和品系调查表明，In和Ahh位点相同或紧密连锁。
相似文献
1
Genetic relationship between aryl hydrocarbon hydroxylase inducibility and chemical carcinogen induced skin ulceration in mice.小鼠中芳烃羟化酶诱导性与化学致癌物诱发皮肤溃疡之间的遗传关系。
Genetics. 1973 Aug;74(4):655-9. doi: 10.1093/genetics/74.4.655.
2
3
Aryl hydrocarbon (benzo ( ) pyrene) hydroxylase: inducible in extrahepatic tissues of mouse strains not inducible in liver.芳基烃（苯并（α）芘）羟化酶：在小鼠品系的肝外组织中可诱导，而在肝脏中不可诱导。
Arch Biochem Biophys. 1973 Jan;154(1):292-4. doi: 10.1016/0003-9861(73)90060-x.
4
Genetic differences in aryl hydrocarbon hydroxylase induction and benzo(a)pyrene-produced tumorigenesis in the mouse.小鼠中芳烃羟化酶诱导及苯并(a)芘所致肿瘤发生的遗传差异。
Mol Pharmacol. 1973 Mar;9(2):266-77.
5
Effects of methylcholanthrene and benzanthracene on blastogenesis and aryl hydrocarbon hydroxylase induction in splenic lymphocytes from three inbred strains of mice.甲基胆蒽和苯并蒽对三种近交系小鼠脾淋巴细胞增殖及芳烃羟化酶诱导的影响。
Int J Immunopharmacol. 1983;5(2):123-9. doi: 10.1016/0192-0561(83)90003-6.
6
Genetic expression of aryl hydrocarbon hydroxylase induction. Evidence for the involvement of other genetic loci.
J Biol Chem. 1974 Sep 25;249(18):5851-9.
7
The genetics of aryl hydrocarbon hydroxylase induction in mice: a single gene difference between C57BL-6J and DBA-2J.小鼠中芳烃羟化酶诱导的遗传学：C57BL - 6J和DBA - 2J之间的单基因差异。
Biochem Genet. 1972 Apr;6(2):157-68. doi: 10.1007/BF00486400.
8
9
10
Genetic expression of aflatoxin metabolism. Effects of 3-methylcholanthrene and beta-naphthoflavone on hepatic microsomal metabolism and mutagenic activation of aflatoxins.黄曲霉毒素代谢的基因表达。3-甲基胆蒽和β-萘黄酮对肝微粒体黄曲霉毒素代谢及诱变激活的影响。
Biochem Pharmacol. 1983 Dec 15;32(24):3755-63. doi: 10.1016/0006-2952(83)90146-6.
引用本文的文献
1
Genetic differences in susceptibility to chemically induced myelotoxicity and leukemia.化学诱导的骨髓毒性和白血病易感性的遗传差异。
Environ Health Perspect. 1981 Jun;39:11-22. doi: 10.1289/ehp.813911.
2
Aryl hydrocarbon hydroxylase induction by benzo[a]anthracene: regulatory gene localized to the distal portion of mouse chromosome 17.苯并[a]蒽对芳烃羟化酶的诱导作用：调控基因定位于小鼠第17号染色体的远端部分。
Genetics. 1984 Jul;107(3):447-61. doi: 10.1093/genetics/107.3.447.
3
Effects of structure on binding to the 2,3,7,8-TCDD receptor protein and AHH induction--halogenated biphenyls.结构对与2,3,7,8-四氯二苯并对二恶英受体蛋白结合及芳烃羟化酶诱导的影响——卤代联苯
Environ Health Perspect. 1985 Sep;61:21-33. doi: 10.1289/ehp.856121.
4
Lack of ecotropic virus involvement in induction of lymphomas in DBA/2J mice by 7,12-dimethylbenz(a)anthracene.7,12-二甲基苯并(a)蒽诱导DBA/2J小鼠淋巴瘤过程中亲嗜性病毒未参与其中。
J Virol. 1990 Oct;64(10):5199-203. doi: 10.1128/JVI.64.10.5199-5203.1990.
5
Mouse chromosome 12.小鼠12号染色体。
Mamm Genome. 1992;3 Spec No:S182-94. doi: 10.1007/BF00648430.
6
Genetic aspects of toxicity during development.发育过程中毒性的遗传学方面。
Environ Health Perspect. 1976 Dec;18:35-45. doi: 10.1289/ehp.761835.
7
The genetic basis of susceptibility to leukemia induction in mice by 3-methylcholanthrene applied percutaneously.经皮应用3-甲基胆蒽诱导小鼠白血病易感性的遗传基础。
J Exp Med. 1978 Feb 1;147(2):459-69. doi: 10.1084/jem.147.2.459.
8
Metabolism of a prototype mycotoxin, aflatoxin B1, and its genetic regulation.一种原型霉菌毒素——黄曲霉毒素B1的代谢及其基因调控。
Mycopathologia. 1978 Dec 18;65(1-3):13-28. doi: 10.1007/BF00447170.
本文引用的文献
1
Dimethylbenzanthracene tumorigenesis and aryl hydrocarbon hydroxylase in mouse skin: inhibition by 7,8-benzoflavone.二甲基苯并蒽在小鼠皮肤中的肿瘤发生及芳烃羟化酶：7,8-苯并黄酮的抑制作用
Science. 1970 Oct 9;170(3954):169-71. doi: 10.1126/science.170.3954.169.
2
3
Epoxides of carcinogenic polycyclic hydrocarbons are frameshift mutagens.致癌多环烃的环氧化物是移码诱变剂。
Science. 1972 Apr 7;176(4030):47-9. doi: 10.1126/science.176.4030.47.
4
[Thin layer chromatographic separation and spectrophoto-fluometric identification of psychotropic drugs].
Arzneimittelforschung. 1969 Dec;19(12):1965-71.
5
Host-gene control of C-type RNA tumor virus: inheritance of the group-specific antigen of murine leukemia virus.C型RNA肿瘤病毒的宿主基因控制：小鼠白血病病毒群特异性抗原的遗传
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3190-4. doi: 10.1073/pnas.68.12.3190.
6
Enzymatic hydroxylation of benzopyrene and its relationship to cytotoxicity.苯并芘的酶促羟基化作用及其与细胞毒性的关系。
Proc Natl Acad Sci U S A. 1969 Dec;64(4):1188-94. doi: 10.1073/pnas.64.4.1188.
7
Genetic regulation of aryl hydrocarbon hydroxylase induction. II. Simple Mendelian expression in mouse tissues in vivo.芳烃羟化酶诱导的遗传调控。II. 小鼠组织在体内的简单孟德尔式表达。
J Biol Chem. 1972 Feb 25;247(4):1125-37.
8
In vitro transformation of rodent cells by K-region derivatives of polycyclic hydrocarbons.多环烃K区域衍生物对啮齿动物细胞的体外转化
Proc Natl Acad Sci U S A. 1971 Jun;68(6):1098-101. doi: 10.1073/pnas.68.6.1098.
Zotero 插件