新型β-内酰胺类抗生素及其他抗菌药物对妇产科感染分离出的厌氧菌的体外活性
In vitro activity of new beta-lactam antibiotics and other antimicrobial drugs against anaerobic isolates from obstetric and gynecological infections.
作者信息
Ohm-Smith M J, Hadley W K, Sweet R L
出版信息
Antimicrob Agents Chemother. 1982 Oct;22(4):711-4. doi: 10.1128/AAC.22.4.711.
Abstract
The in vitro activities of N-formimidoyl thienamycin, clindamycin, chloramphenicol, metronidazole, cefoperazone, cefotaxime, cefoxitin, moxalactam, penicillin G, and piperacillin were determined against 158 anaerobic bacteria isolated from endometrial wash cultures of women with pelvic infections. In general, N-formimidoyl thienamycin was the most active, with all organisms inhibited by less than or equal to 0.5 microgram/ml. Chloramphenicol, clindamycin, and metronidazole inhibited all organisms by less than or equal to 8 microgram/ml. The penicillins and cephalosporins exhibited variable activity of lesser degrees.
摘要
测定了N-甲酰亚胺硫霉素、克林霉素、氯霉素、甲硝唑、头孢哌酮、头孢噻肟、头孢西丁、拉氧头孢、青霉素G和哌拉西林对从盆腔感染女性子宫内膜冲洗培养物中分离出的158株厌氧菌的体外活性。总体而言，N-甲酰亚胺硫霉素活性最强，所有菌株均被小于或等于0.5微克/毫升的浓度所抑制。氯霉素、克林霉素和甲硝唑对所有菌株的抑制浓度均小于或等于8微克/毫升。青霉素和头孢菌素的活性程度各不相同且较低。
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本文引用的文献
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In vitro activity of N-formimidoyl thienamycin (MK0787).N-甲酰亚胺基硫霉素（MK0787）的体外活性
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