Kozak C A, Rowe W P
J Exp Med. 1980 Jul 1;152(1):219-28. doi: 10.1084/jem.152.1.219.
A single mendelian gene was identified for induction of the endogenous xenotropic murine leukemia virus in five mouse strains (C57BL/10, C57L, C57BR, AKR, and BALB/c). This locus, designated Bxv-1, mapped to the same site on chromosome 1 in all strains: Id-1-Pep-3-[Bxv-1-Lp]. Thus, inducibility loci for xenotropic virus are more limited in number and chromosomal distribution than ecotropic inducibility loci. Virus expression in mice with Bxv-1 was induced by treatment of fibroblasts with 5-iododeoxyuridine or by exposure of spleen cells to a B cell mitogen, bacterial lipopolysaccharide. An analysis of the hamster X mouse somatic cell hybrids indicated that chromosome 1, alone, was sufficient for virus induction.
在五个小鼠品系(C57BL/10、C57L、C57BR、AKR和BALB/c)中,鉴定出一个单孟德尔基因可诱导内源性嗜异性鼠白血病病毒。这个位点被命名为Bxv-1,在所有品系中都定位到1号染色体上的同一位点:Id-1-Pep-3-[Bxv-1-Lp]。因此,嗜异性病毒的诱导位点在数量和染色体分布上比亲嗜性诱导位点更有限。用5-碘脱氧尿苷处理成纤维细胞或使脾细胞暴露于B细胞有丝分裂原细菌脂多糖,可诱导带有Bxv-1的小鼠体内病毒表达。对仓鼠×小鼠体细胞杂种的分析表明,单独的1号染色体就足以诱导病毒产生。