F/St小鼠中逆转录病毒表达的独特特征。
Unique features of retrovirus expression in F/St mice.
作者信息
Morse H C, Kozak C A, Yetter R A, Hartley J W
出版信息
J Virol. 1982 Jul;43(1):1-7. doi: 10.1128/JVI.43.1.1-7.1982.
Abstract
F/St mice are unique in producing high levels of both ecotropic and xenotropic murine leukemia virus. The high ecotropic virus phenotype is determined by three or more V (virus-inducing) loci. A single locus for inducibility of xenotropic murine leukemia virus was mapped to chromosome 1 close to, but possibly not allelic to, Bxv-1. Although the high ecotropic virus phenotype is phenotypically dominant, the high xenotropic virus phenotype was recessive in all crosses tested. Suppression of xenotropic murine leukemia virus is governed by a single gene which is not linked to the xenotropic V locus.
摘要
F/St小鼠的独特之处在于能产生高水平的嗜亲性和异嗜性鼠白血病病毒。高嗜亲性病毒表型由三个或更多的V（病毒诱导）基因座决定。异嗜性鼠白血病病毒诱导性的单个基因座被定位到靠近Bxv - 1但可能与其非等位的1号染色体上。尽管高嗜亲性病毒表型在表型上是显性的，但高异嗜性病毒表型在所有测试的杂交中都是隐性的。异嗜性鼠白血病病毒的抑制由一个与异嗜性V基因座不连锁的单一基因控制。
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