van Hardeveld C, Zuidwijk M, Kassenaar A A
Horm Metab Res. 1980;12(6):264-9. doi: 10.1055/s-2007-996263.
Hind-limb perfusion was used to investigate alterations of alpha and beta receptor-mediated metabolic effects in cold-adapted (CA) rats. The response to beta receptor stimulation by isoproterenol in the isolated hind-limbs of CA rats was slightly diminished. Oxygen consumption and lactate production were reduced in CA rats after beta receptor stimulation. Noradrenalin infusion caused less vasoconstriction in CA rats than in the controls (CO). Desensitization of alpha and beta receptors due to chronic sympathetic overstimulation may be the underlying cause of these observations. Compared with the controls, metabolism was enhanced in perfused hind-limbs of CA rats with an active nervous system. Decreased vascular resistance due to the lower perfusion pressure in CA rats might contribute to this increased metabolism.
采用后肢灌注法研究冷适应（CA）大鼠α和β受体介导的代谢效应变化。异丙肾上腺素对CA大鼠离体后肢β受体的刺激反应略有减弱。β受体刺激后，CA大鼠的耗氧量和乳酸生成量减少。与对照组（CO）相比，去甲肾上腺素输注在CA大鼠中引起的血管收缩较小。慢性交感神经过度刺激导致的α和β受体脱敏可能是这些观察结果的潜在原因。与对照组相比，具有活跃神经系统的CA大鼠灌注后肢的代谢增强。CA大鼠较低的灌注压力导致血管阻力降低，这可能是代谢增加的原因。
