Butcher B T, O'Neil C E, Reed M A, Salvaggio J E
J Allergy Clin Immunol. 1980 Sep;66(3):213-6. doi: 10.1016/0091-6749(80)90041-x.
Serum from 26 persons shown to react to provocative inhalation challenge with low concentration of toluene diisocyanate (TDI) was tested by radioallergosorbent test (RAST) using a p-tolyl isocyanate-human serum albumin (TMI-HSA) conjugate. Results were evaluated by the RAST ratio and by the mean +3 standard deviation methods. Positive results were obtained in 15% to 19% of TDI reactors, depending on the method of evaluation. These findings suggest that TDI asthma may be a complex syndrome with several types of reaction possible, including an IgE mechanism in some individuals, but they do not support the theory that TDI asthma is based solely on an immune mechanism. However, they do not disagree with the hypothesis that TDI reactivity may be mediated by a pharmacologic mechanism.
用对甲苯基异氰酸酯-人血清白蛋白（TMI-HSA）结合物，通过放射变应原吸附试验（RAST）对26名已证明对低浓度甲苯二异氰酸酯（TDI）激发吸入试验有反应者的血清进行检测。结果通过RAST比值和均值加3个标准差方法进行评估。根据评估方法的不同，在15%至19%的TDI反应者中获得了阳性结果。这些发现提示，TDI哮喘可能是一种复杂的综合征，可能有几种反应类型，包括某些个体中的IgE机制，但它们并不支持TDI哮喘仅基于免疫机制的理论。然而，它们也不反对TDI反应性可能由药理机制介导的假说。
