介导镇痛作用的阿片受体的进一步研究：犬牙髓刺激实验
Further studies on opiate receptors that mediate antinoception: tooth pulp stimulation in the dog.
作者信息
Skingle M, Tyers M B
出版信息
Br J Pharmacol. 1980 Oct;70(2):323-7. doi: 10.1111/j.1476-5381.1980.tb07939.x.
Abstract
1 The antinociceptive activities of morphine, codeine and dextropropoxyphene (micro-agonists), buprenorphine and Mr 2034 (-)5,9-dimethyl-2-(tetrahydrofurfuryl)-2'-hydroxy-6,7-benzomorphan have been determined against nociceptive responses to electrical stimulation of the tooth pulp in the conscious dog. 2 Dose-dependent increases in nociceptive threshold were obtained for all of the analgesic drugs tested at doses within their antinociceptive range as determined in nociceptive pressure and chemical tests in rodents.
摘要
- 已经针对清醒犬牙髓电刺激的伤害性反应，测定了吗啡、可待因和右丙氧芬（微激动剂）、丁丙诺啡和Mr 2034 [(-)5,9-二甲基-2-(四氢糠基)-2'-羟基-6,7-苯并吗啡烷]（κ激动剂）的抗伤害感受活性。2. 在所测试的所有镇痛药中，在啮齿动物的伤害性压力和化学测试所确定的抗伤害感受范围内的剂量下，均获得了剂量依赖性的伤害性阈值升高。
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Sensory mechanisms in mammalian teeth and their supporting structures.哺乳动物牙齿及其支持结构中的感觉机制。
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