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1
Picornaviral VPg sequences are contained in the replicase precursor.小核糖核酸病毒VPg序列包含在复制酶前体中。
J Virol. 1980 Aug;35(2):414-9. doi: 10.1128/JVI.35.2.414-419.1980.
2
Evidence for intramolecular self-cleavage of picornaviral replicase precursors.微小核糖核酸病毒复制酶前体分子内自我切割的证据。
J Virol. 1982 Jan;41(1):244-9. doi: 10.1128/JVI.41.1.244-249.1982.
3
Anti-VPg antibody inhibition of the poliovirus replicase reaction and production of covalent complexes of VPg-related proteins and RNA.抗VPg抗体对脊髓灰质炎病毒复制酶反应的抑制作用以及VPg相关蛋白与RNA共价复合物的产生。
Cell. 1982 Oct;30(3):745-52. doi: 10.1016/0092-8674(82)90279-3.
4
Characterization of the large picornaviral polypeptides produced in the presence of zinc ion.锌离子存在下产生的大微小核糖核酸病毒多肽的特性分析。
J Virol. 1974 Aug;14(2):282-91. doi: 10.1128/JVI.14.2.282-291.1974.
5
Poliovirus replication proteins: RNA sequence encoding P3-1b and the sites of proteolytic processing.脊髓灰质炎病毒复制蛋白：编码P3-1b的RNA序列及蛋白水解加工位点。
Proc Natl Acad Sci U S A. 1981 Jun;78(6):3464-8. doi: 10.1073/pnas.78.6.3464.
6
Characterization of protein-protein interactions critical for poliovirus replication: analysis of 3AB and VPg binding to the RNA-dependent RNA polymerase.对脊髓灰质炎病毒复制至关重要的蛋白质-蛋白质相互作用的表征：3AB和VPg与RNA依赖性RNA聚合酶结合的分析
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7
The structure of the covalent linkage between proteins and RNA in encephalomyocarditis virus.脑心肌炎病毒中蛋白质与RNA之间共价连接的结构。
Nucleic Acids Res. 1980 Aug 25;8(16):3729-42. doi: 10.1093/nar/8.16.3729.
8
A detailed kinetic analysis of the in vitro synthesis and processing of encephalomyocarditis virus products.脑心肌炎病毒产物体外合成与加工的详细动力学分析。
Virology. 1986 Feb;149(1):114-27. doi: 10.1016/0042-6822(86)90092-9.
9
Antibody to a synthetic nonapeptide corresponding to the NH2 terminus of poliovirus genome-linked protein VPg reacts with native VPg and inhibits in vitro replication of poliovirus RNA.针对与脊髓灰质炎病毒基因组连接蛋白VPg的NH2末端相对应的合成九肽的抗体，可与天然VPg发生反应，并抑制脊髓灰质炎病毒RNA的体外复制。
J Virol. 1983 Nov;48(2):429-39. doi: 10.1128/JVI.48.2.429-439.1983.
10
Protease required for processing picornaviral coat protein resides in the viral replicase gene.加工微小核糖核酸病毒衣壳蛋白所需的蛋白酶存在于病毒复制酶基因中。
J Virol. 1979 Dec;32(3):770-8. doi: 10.1128/JVI.32.3.770-778.1979.

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1
Picornavirus 3C Proteins Intervene in Host Cell Processes through Proteolysis and Interactions with RNA.小核糖核酸病毒 3C 蛋白通过蛋白水解和与 RNA 的相互作用来干预宿主细胞的过程。
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Prolonged Primary Rhinovirus Infection of Human Nasal Epithelial Cells Diminishes the Viral Load of Secondary Influenza H3N2 Infection via the Antiviral State Mediated by RIG-I and Interferon-Stimulated Genes.人鼻腔上皮细胞内持续性鼻病毒感染通过 RIG-I 和干扰素刺激基因介导的抗病毒状态减弱了继发 H3N2 流感病毒感染的病毒载量。
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4
The Language of Life.生命的语言。
Annu Rev Virol. 2016 Sep 29;3(1):1-28. doi: 10.1146/annurev-virology-110615-035544.
5
SUMOylation promotes PML degradation during encephalomyocarditis virus infection.SUMOylation 促进脑炎心肌炎病毒感染期间 PML 的降解。
J Virol. 2010 Nov;84(22):11634-45. doi: 10.1128/JVI.01321-10. Epub 2010 Sep 8.
6
Expression of the Bottom-Component RNA of Cowpea Mosaic Virus: Evidence that the 60-Kilodalton VPg Precursor Is Cleaved into Single VPg and a 58-Kilodalton Polypeptide.豇豆花叶病毒底部组分RNA的表达：60千道尔顿VPg前体被切割成单个VPg和一个58千道尔顿多肽的证据
J Virol. 1982 May;42(2):630-5. doi: 10.1128/JVI.42.2.630-635.1982.
7
Antibodies Against the Genome-Linked Protein VPg of Cowpea Mosaic Virus Recognize a 60,000-Dalton Precursor Polypeptide.抗豇豆花叶病毒基因组连接蛋白VPg的抗体识别一种60,000道尔顿的前体多肽。
J Virol. 1982 Mar;41(3):1083-8. doi: 10.1128/JVI.41.3.1083-1088.1982.
8
The nucleotide and deduced amino acid sequences of the encephalomyocarditis viral polyprotein coding region.脑心肌炎病毒多聚蛋白编码区的核苷酸序列及推导的氨基酸序列。
Nucleic Acids Res. 1984 Mar 26;12(6):2969-85. doi: 10.1093/nar/12.6.2969.
9
Biochemical map of polypeptides specified by foot-and-mouth disease virus.口蹄疫病毒指定的多肽生化图谱。
J Virol. 1984 May;50(2):579-86. doi: 10.1128/JVI.50.2.579-586.1984.
10
ATP is required for initiation of poliovirus RNA synthesis in vitro: demonstration of tyrosine-phosphate linkage between in vitro-synthesized RNA and genome-linked protein.体外脊髓灰质炎病毒RNA合成起始需要ATP：体外合成的RNA与基因组连接蛋白之间酪氨酸磷酸键的证明。
J Virol. 1984 May;50(2):515-23. doi: 10.1128/JVI.50.2.515-523.1984.

本文引用的文献

1
Changes in three of the four coat proteins of oral polio vaccine strain derived from type 1 poliovirus.源自1型脊髓灰质炎病毒的口服脊髓灰质炎疫苗株的四种衣壳蛋白中的三种发生了变化。
J Virol. 1980 Jan;33(1):256-63. doi: 10.1128/JVI.33.1.256-263.1980.
2
Infection of mouse fibroblasts by cardioviruses: premature uncoating and its prevention by elevated pH and magnesium chloride.心肌病毒对小鼠成纤维细胞的感染：过早脱壳以及通过提高pH值和添加氯化镁对其进行预防
Virology. 1971 Jan;43(1):152-65. doi: 10.1016/0042-6822(71)90233-9.
3
Characterization of the large picornaviral polypeptides produced in the presence of zinc ion.锌离子存在下产生的大微小核糖核酸病毒多肽的特性分析。
J Virol. 1974 Aug;14(2):282-91. doi: 10.1128/JVI.14.2.282-291.1974.
4
A proposed regulator for poliovirus: the equestron.一种提议的脊髓灰质炎病毒调节剂：马雌激素。
Intervirology. 1973;1(1):1-10. doi: 10.1159/000148826.
5
A comparison of the virus-specific polypeptides of encephalomyocarditis virus, human rhinovirus-1A, and poliovirus.脑心肌炎病毒、人鼻病毒1A和脊髓灰质炎病毒的病毒特异性多肽比较
Virology. 1973 Dec;56(2):439-53. doi: 10.1016/0042-6822(73)90048-2.
6
Gene order of encephalomyocarditis virus as determined by studies with pactamycin.通过用 pactamycin 进行的研究确定的脑心肌炎病毒的基因顺序。
J Virol. 1972 May;9(5):823-8. doi: 10.1128/JVI.9.5.823-828.1972.
7
Virus-specific proteins synthesized in encephalomyocarditis virus-infected HeLa cells.在脑心肌炎病毒感染的HeLa细胞中合成的病毒特异性蛋白。
Proc Natl Acad Sci U S A. 1971 Dec;68(12):3083-7. doi: 10.1073/pnas.68.12.3083.
8
On the structure of rhinovirus 1A.关于鼻病毒1A的结构
Virology. 1971 May;44(2):259-70. doi: 10.1016/0042-6822(71)90258-3.
9
Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells.脊髓灰质炎病毒感染的HeLa细胞中病毒特异性非衣壳蛋白的证据。
Proc Natl Acad Sci U S A. 1965 Aug;54(2):505-13. doi: 10.1073/pnas.54.2.505.
10
Protease required for processing picornaviral coat protein resides in the viral replicase gene.加工微小核糖核酸病毒衣壳蛋白所需的蛋白酶存在于病毒复制酶基因中。
J Virol. 1979 Dec;32(3):770-8. doi: 10.1128/JVI.32.3.770-778.1979.

小核糖核酸病毒VPg序列包含在复制酶前体中。

Picornaviral VPg sequences are contained in the replicase precursor.

作者信息

Pallansch M A, Kew O M, Palmenberg A C, Golini F, Wimmer E, Rueckert R R

出版信息

J Virol. 1980 Aug;35(2):414-9. doi: 10.1128/JVI.35.2.414-419.1980.

DOI:10.1128/JVI.35.2.414-419.1980
PMID:6255181
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC288826/
Abstract

It has previously been shown that the RNA replicase of encephalomyocarditis virus contains two virus-coded proteins, D and E, which are produced in two successive proteolytic steps: (i) C leads to D + ?; and (ii) D leads to p22 + E. It is here shown (i) that virus protein H (molecular weight, 12,000) is the previously unidentified product of the first step and (ii) that VPg, a protein linked covalently to the virion RNA, yields two tryptic peptides found in protein C but not in protein D. The results suggest that VPg is derived by cleavage of protein C and that protein H may be intermediate. Preliminary experiments with VPg sequences in polioviral noncapsid protein 1b, the counterpart of encephalomyocarditis viral protein C, were inconclusive.

摘要

先前的研究表明，脑心肌炎病毒的RNA复制酶包含两种病毒编码蛋白，D和E，它们通过两个连续的蛋白水解步骤产生：（i）C产生D +？； （ii）D产生p22 + E。本文表明：（i）病毒蛋白H（分子量12,000）是第一步中先前未鉴定的产物； （ii）与病毒体RNA共价连接的蛋白VPg产生了在蛋白C中发现但在蛋白D中未发现的两种胰蛋白酶肽。结果表明，VPg是由蛋白C裂解产生的，蛋白H可能是中间产物。对脊髓灰质炎病毒非衣壳蛋白1b（脑心肌炎病毒蛋白C的对应物）中的VPg序列进行的初步实验尚无定论。