Trang L E, Lövgren O, Bendz R, Mjös O
Scand J Rheumatol. 1980;9(4):229-33. doi: 10.3109/03009748009112353.
Cyclic adenosine-3', 5'-monophosphate (cAMP) may influence important mechanisms in the inflammatory process, and fasting has been claimed to be clinically beneficial in rheumatoid arthritis (RA). A study was therefore designed to measure the concentrations of plasma cAMP in RA patients not undergoing drug treatment during a control and a fasting period. Twelve female RA patients were hospitalized for two 14-day periods and investigated in a crossover study. Clinical and laboratory variables of inflammatory activity were assessed during both periods. During the control period the concentrations of cAMP in plasma were slightly below the lower normal limit, with no significant change throughout the period. The clinical and laboratory variables of inflammatory activity were unchanged during the same period. In the fasting period, the prefasting level of plasma cAMP was significantly higher than on the corresponding day in the control period. During 7 days of total fasting the plasma cAMP concentrations decreased significantly. The clinical and laboratory variables of inflammatory activity decreased significantly from the start to the end of fasting. High prefasting plasma cAMP concentrations were associated with improvement in clinical inflammatory activity. A decrease in plasma cAMP concentrations during fasting in RA patients is in contrast to the findings in obese and healthy subjects previously reported.
环磷腺苷（cAMP）可能影响炎症过程中的重要机制，并且禁食据称在类风湿关节炎（RA）中具有临床益处。因此，设计了一项研究来测量在对照期和禁食期未接受药物治疗的RA患者血浆cAMP的浓度。12名女性RA患者住院两个14天周期，并在交叉研究中进行调查。在两个周期中均评估了炎症活动的临床和实验室变量。在对照期，血浆中cAMP的浓度略低于正常下限，整个期间无显著变化。同期炎症活动的临床和实验室变量未改变。在禁食期，禁食前血浆cAMP水平显著高于对照期的相应日期。在完全禁食的7天中，血浆cAMP浓度显著下降。从禁食开始到结束，炎症活动的临床和实验室变量显著下降。禁食前血浆cAMP浓度高与临床炎症活动的改善相关。RA患者禁食期间血浆cAMP浓度的下降与先前报道的肥胖和健康受试者的结果相反。
