• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

苯唑西林水解青霉素酶基因的转位

Transposition of the oxacillin-hydrolyzing penicillinase gene.

作者信息

Yamamoto T, Tanaka M, Nohara C, Fukunaga Y, Yamagishi S

出版信息

J Bacteriol. 1981 Feb;145(2):808-13. doi: 10.1128/jb.145.2.808-813.1981.

DOI:10.1128/jb.145.2.808-813.1981
PMID:6257651
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC217183/
Abstract

We have found that the oxacillin-hydrolyzing penicillinase gene (oxa) encoded by plasmid RGN238 transposes to various plasmids in a recA background. We call this transposable element Tn2603. Tn2603 encodes the genes for streptomycin, sulfonamide, and mercury resistance in addition to the oxa gene. Tn2603 has a molecular size of 19.6 kilobase pairs and appears to be flanked by small inverted repeat sequences of about 200 base pairs long.

摘要

我们发现，质粒RGN238编码的水解苯唑西林的青霉素酶基因（oxa）在recA背景下可转移至各种质粒。我们将这种转座元件称为Tn2603。除oxa基因外，Tn2603还编码链霉素、磺胺和汞抗性基因。Tn2603的分子大小为19.6千碱基对，其两侧似乎是约200个碱基对长的小反向重复序列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/455f/217183/423f4c636df0/jbacter00273-0147-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/455f/217183/9e8f91d76c0a/jbacter00273-0146-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/455f/217183/a4972423f44f/jbacter00273-0146-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/455f/217183/423f4c636df0/jbacter00273-0147-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/455f/217183/9e8f91d76c0a/jbacter00273-0146-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/455f/217183/a4972423f44f/jbacter00273-0146-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/455f/217183/423f4c636df0/jbacter00273-0147-a.jpg

相似文献

1
Transposition of the oxacillin-hydrolyzing penicillinase gene.苯唑西林水解青霉素酶基因的转位
J Bacteriol. 1981 Feb;145(2):808-13. doi: 10.1128/jb.145.2.808-813.1981.
2
Tn2011, a new transposon encoding oxacillin-hydrolyzing beta-lactamase.Tn2011，一种编码水解苯唑西林的β-内酰胺酶的新型转座子。
Antimicrob Agents Chemother. 1983 Mar;23(3):407-12. doi: 10.1128/AAC.23.3.407.
3
Tn2610, a transposon involved in the spread of the carbenicillin-hydrolyzing beta-lactamase gene.Tn2610，一种与羧苄青霉素水解β-内酰胺酶基因传播有关的转座子。
Mol Gen Genet. 1983;189(2):282-8. doi: 10.1007/BF00337818.
4
Genesis of a complex transposon encoding the OXA-1 (type II) beta-lactamase gene.编码OXA-1（II型）β-内酰胺酶基因的复合转座子的起源
Antimicrob Agents Chemother. 1985 Aug;28(2):227-34. doi: 10.1128/AAC.28.2.227.
5
Transposition of a gene encoding OXA-2 beta-lactamase.编码OXA-2β-内酰胺酶的基因转位。
J Gen Microbiol. 1983 Sep;129(9):2951-7. doi: 10.1099/00221287-129-9-2951.
6
Penicillinase-producing Neisseria gonorrhoeae: a molecular comparison of 5.3-kb and 7.4-kb beta-lactamase plasmids.产青霉素酶淋病奈瑟菌：5.3kb和7.4kbβ-内酰胺酶质粒的分子比较
J Bacteriol. 1982 Sep;151(3):1171-5. doi: 10.1128/jb.151.3.1171-1175.1982.
7
Precise insertion of antibiotic resistance determinants into Tn21-like transposons: nucleotide sequence of the OXA-1 beta-lactamase gene.抗生素抗性决定簇精确插入Tn21样转座子：OXA-1β-内酰胺酶基因的核苷酸序列
Proc Natl Acad Sci U S A. 1987 Nov;84(21):7378-82. doi: 10.1073/pnas.84.21.7378.
8
A gene and its product required for transposition of resistance transposon Tn2603.抗性转座子Tn2603转座所需的一个基因及其产物。
J Bacteriol. 1982 Aug;151(2):723-8. doi: 10.1128/jb.151.2.723-728.1982.
9
Transposition of the carbenicillin-hydrolyzing beta-lactamase gene.羧苄青霉素水解β-内酰胺酶基因的转位
J Bacteriol. 1982 May;150(2):483-9. doi: 10.1128/jb.150.2.483-489.1982.
10
Physical and functional mapping of Tn2603, a transposon encoding ampicillin, streptomycin, sulfonamide, and mercury resistance.Tn2603转座子的物理和功能图谱，该转座子编码氨苄青霉素、链霉素、磺胺类药物和汞抗性。
Mol Gen Genet. 1981;181(4):464-9. doi: 10.1007/BF00428737.

引用本文的文献

1
Human Salmonella and concurrent decreased susceptibility to quinolones and extended-spectrum cephalosporins.人感染沙门氏菌以及对喹诺酮类和广谱头孢菌素的敏感性同时降低。
Emerg Infect Dis. 2007 Nov;13(11):1681-8. doi: 10.3201/eid1311.061438.
2
Effects of efflux transporter genes on susceptibility of Escherichia coli to tigecycline (GAR-936).外排转运蛋白基因对大肠杆菌对替加环素（GAR-936）敏感性的影响。
Antimicrob Agents Chemother. 2004 Jun;48(6):2179-84. doi: 10.1128/AAC.48.6.2179-2184.2004.
3
Role of histone-like protein H-NS in multidrug resistance of Escherichia coli.

本文引用的文献

1
Gene expression of ampicillin resistance transposons, Tn2601 and Tn2602.
Microbiol Immunol. 1980;24(6):479-94. doi: 10.1111/j.1348-0421.1980.tb02852.x.
2
R-factor mediated beta-lactamase in Pseudomonas aeruginosa.铜绿假单胞菌中R因子介导的β-内酰胺酶
Nature. 1970 Jun 13;226(5250):1054-6. doi: 10.1038/2261054a0.
3
The purification and properties of penicillin beta-lactamases mediated by transmissible R factors in Escherichia coli.大肠杆菌中由可传递R因子介导的青霉素β-内酰胺酶的纯化及特性
组蛋白样蛋白H-NS在大肠杆菌多重耐药性中的作用
J Bacteriol. 2004 Mar;186(5):1423-9. doi: 10.1128/JB.186.5.1423-1429.2004.
4
Comprehensive studies of drug resistance mediated by overexpression of response regulators of two-component signal transduction systems in Escherichia coli.大肠杆菌中两组分信号转导系统响应调节因子过表达介导的耐药性综合研究。
J Bacteriol. 2003 Mar;185(6):1851-6. doi: 10.1128/JB.185.6.1851-1856.2003.
5
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.假定的反应调节因子BaeR通过一种新型多药输出系统MdtABC刺激大肠杆菌的多药耐药性。
J Bacteriol. 2002 Aug;184(15):4161-7. doi: 10.1128/JB.184.15.4161-4167.2002.
6
EvgA of the two-component signal transduction system modulates production of the yhiUV multidrug transporter in Escherichia coli.双组分信号转导系统的EvgA调节大肠杆菌中yhiUV多药转运蛋白的产生。
J Bacteriol. 2002 Apr;184(8):2319-23. doi: 10.1128/JB.184.8.2319-2323.2002.
7
Analysis of a complete library of putative drug transporter genes in Escherichia coli.大肠杆菌中假定药物转运蛋白基因完整文库的分析。
J Bacteriol. 2001 Oct;183(20):5803-12. doi: 10.1128/JB.183.20.5803-5812.2001.
8
A novel glycylcycline, 9-(N,N-dimethylglycylamido)-6-demethyl-6-deoxytetracycline, is neither transported nor recognized by the transposon Tn10-encoded metal-tetracycline/H+ antiporter.一种新型甘氨酰环素，9-(N,N-二甲基甘氨酰氨基)-6-去甲基-6-脱氧四环素，既不被转座子Tn10编码的金属-四环素/H+反向转运体转运，也不被其识别。
Antimicrob Agents Chemother. 1995 Jan;39(1):247-9. doi: 10.1128/AAC.39.1.247.
9
Transfer of IncN plasmids to Pseudomonas aeruginosa.IncN质粒向铜绿假单胞菌的转移。
Antimicrob Agents Chemother. 1982 Jul;22(1):142-4. doi: 10.1128/AAC.22.1.142.
10
Properties of PSE-2 beta-lactamase and genetic basis for its production in Pseudomonas aeruginosa.铜绿假单胞菌中PSE-2β-内酰胺酶的特性及其产生的遗传基础。
Antimicrob Agents Chemother. 1983 Sep;24(3):362-9. doi: 10.1128/AAC.24.3.362.
J Biochem. 1969 Jul;66(1):11-20. doi: 10.1093/oxfordjournals.jbchem.a129111.
4
The purification and properties of the -lactamase specified by the resistance factor R-1818 in Escherichia coli and Proteus mirabilis.大肠杆菌和奇异变形杆菌中由抗性因子R - 1818所指定的β - 内酰胺酶的纯化及特性
Biochem J. 1971 Jul;123(4):493-500. doi: 10.1042/bj1230493.
5
Variant of penicillinase mediated by an R factor in Escherichia coli.由大肠杆菌中一种R因子介导的青霉素酶变体。
J Bacteriol. 1970 Nov;104(2):620-9. doi: 10.1128/jb.104.2.620-629.1970.
6
Transposition of ampicillin resistance from RP4 to other replicons.氨苄青霉素抗性从RP4转座至其他复制子。
Mol Gen Genet. 1974;132(1):31-40. doi: 10.1007/BF00268228.
7
Molecular specificities of R factor-determined beta-lactamases: correlation with plasmid compatibility.R因子决定的β-内酰胺酶的分子特异性：与质粒相容性的相关性。
J Bacteriol. 1974 Jan;117(1):56-62. doi: 10.1128/jb.117.1.56-62.1974.
8
Trimethoprim resistance conferred by W plasmids in Enterobacteriaceae.肠杆菌科细菌中W质粒赋予的甲氧苄啶耐药性。
J Gen Microbiol. 1972 Sep;72(2):349-55. doi: 10.1099/00221287-72-2-349.
9
Naturally occurring R factor, derepressed for pilus synthesis, belonging to the same compatibility group as the sex factor F of Escherichia coli K-12.天然存在的R因子，其菌毛合成去阻遏，与大肠杆菌K-12的性因子F属于同一相容群。
J Bacteriol. 1972 Jan;109(1):416-22. doi: 10.1128/jb.109.1.416-422.1972.
10
Analytical isoelectric focusing of R factor-determined beta-lactamases: correlation with plasmid compatibility.R因子决定的β-内酰胺酶的分析性等电聚焦：与质粒相容性的相关性
J Bacteriol. 1976 Feb;125(2):713-8. doi: 10.1128/jb.125.2.713-718.1976.