Rigel D S, Jacobs M I
J Dermatol Surg Oncol. 1980 Nov;6(11):923-7. doi: 10.1111/j.1524-4725.1980.tb01003.x.
Malignant acanthosis nigricans is a dermatosis that appears grossly as a hyperpigmented, velvety, or verrucous hyperplasia of the epidermis, most marked in flexural areas. It is always associated with a malignancy. In 277 cases reviewed, the condition was associated with gastric carcinomas in 55.5%, with other intra-abdominal carcinomas in 17.7%, and with malignancies in other sites in 26.8%. Current theories for the association and pathogenesis of the cutaneous process are discussed.
恶性黑棘皮病是一种皮肤病，肉眼可见为表皮色素沉着过度、天鹅绒样或疣状增生，在屈侧部位最为明显。它总是与恶性肿瘤相关。在回顾的277例病例中，该病症与胃癌相关的占55.5%，与其他腹部内癌症相关的占17.7%，与其他部位恶性肿瘤相关的占26.8%。文中讨论了目前关于皮肤病变关联和发病机制的理论。
