Costa Mariana, Valente Ana, Freire Coelho Andreia, Meireles Sara, Barbosa Miguel
Medical Oncology, Centro Hospitalar Universitário de São João, Porto, PRT.
Cureus. 2023 Mar 7;15(3):e35853. doi: 10.7759/cureus.35853. eCollection 2023 Mar.
We present the case of a 64-year-old woman with type 2 diabetes who was diagnosed with early-stage intrahepatic cholangiocarcinoma and underwent partial hepatectomy followed by adjuvant chemotherapy. The patient simultaneously developed skin lesions compatible with acanthosis nigricans (AN). Thirty-seven months after completing chemotherapy, the patient had a recurrence of extensive skin and mucosal lesions compatible with AN. A thoracic-abdominal-pelvic (TAP) CT showed a relapse with hepatic hilar adenopathy. Currently, she is under evaluation to undergo radical treatment. Malignancy is a rare cause of AN and skin lesions can arise before, during, or after the diagnosis. As a paraneoplastic syndrome, it is usually related to gastric adenocarcinoma, with cholangiocarcinoma being a rare entity in this setting. Although an uncommon manifestation, the malignant etiology should be considered among other prevalent causes, such as metabolic disorders, and establishing an association can lead to an early diagnosis and initiation of curative treatment.
我们报告了一例64岁的2型糖尿病女性患者，该患者被诊断为早期肝内胆管癌，并接受了部分肝切除术，随后进行辅助化疗。该患者同时出现了与黑棘皮病（AN）相符的皮肤病变。完成化疗37个月后，患者出现了与AN相符的广泛皮肤和黏膜病变复发。胸腹部盆腔（TAP）CT显示肝门淋巴结病复发。目前，她正在接受评估以进行根治性治疗。恶性肿瘤是AN的罕见病因，皮肤病变可在诊断之前、期间或之后出现。作为一种副肿瘤综合征，它通常与胃腺癌有关，在这种情况下胆管癌是罕见的情况。虽然是一种不常见的表现，但在其他常见病因（如代谢紊乱）中应考虑恶性病因，建立关联可导致早期诊断和启动治愈性治疗。
