Arellano Javier, Iglesias Pamela, Suarez Claudia, Corredoira Yamile, Schnettler Katty
Department of Dermatology, University of Chile, Santiago, Chile.
Department of Dermatology, Hospital Clínico San Borja, Arriarán, Chile.
Int J Womens Dermatol. 2019 Mar 21;5(3):183-186. doi: 10.1016/j.ijwd.2019.03.002. eCollection 2019 Jul.
Malignant acanthosis nigricans is a rare paraneoplastic syndrome, usually associated with a gastric adenocarcinoma and less frequently with other neoplasms. In general, its appearance indicates a poor prognosis with a survival of < 2 years. We describe the case of a 40-year-old patient who presented with generalized cutaneous thickening that had a velvety appearance, was rapidly progressing, and involved right axillary adenopathy. Skin and nipple biopsy yielded results consistent with acanthosis nigricans, and palpable adenopathy biopsy results were compatible with mammary adenocarcinoma (human epidermal growth factor receptor 2 positive and estrogen and progesterone receptor negative) without a detectable primary tumor. This case of malignant acanthosis nigricans is presented because of the importance of its early recognition as a paraneoplastic syndrome and its relation with mammary adenocarcinoma, an association infrequently reported in the literature.
恶性黑棘皮病是一种罕见的副肿瘤综合征，通常与胃腺癌相关，较少与其他肿瘤相关。一般来说，其出现预示预后不良，生存期<2年。我们描述了一名40岁患者的病例，该患者出现全身皮肤增厚，呈天鹅绒样外观，进展迅速，并累及右腋窝淋巴结肿大。皮肤和乳头活检结果符合黑棘皮病，可触及的淋巴结活检结果与乳腺腺癌（人表皮生长因子受体2阳性，雌激素和孕激素受体阴性）相符，但未检测到原发性肿瘤。之所以呈现这例恶性黑棘皮病病例，是因为早期识别其作为副肿瘤综合征的重要性及其与乳腺腺癌的关系，这种关联在文献中报道较少。
