Chiarini A, Giovanninetti G, Sinibaldi P, Mannini Palenzona A
Farmaco Sci. 1981 Jan;36(1):33-7.
A few hydrazones with benzofuran and 1H-indene moieties were synthesized and screened in vitro against vaccinia virus strain IHD, parainfluenza type 3 virus strain HA-1/CR-8, and the MP mutant of herpes simplex virus type 1 [HSV-1 (MP)]. Only the thiosemicarbazones were active. The thiosemicarbazone of 3-chloro-2-formyl-1H-indene inhibited vaccinia virus to a greater extent than methisazone, used as reference standard. Furthermore, this compound was active also against parainfluenza and herpes viruses.
合成了几种带有苯并呋喃和1H-茚部分的腙，并针对痘苗病毒株IHD、3型副流感病毒株HA-1/CR-8和1型单纯疱疹病毒的MP突变体[HSV-1(MP)]进行了体外筛选。只有硫代卡巴腙具有活性。3-氯-2-甲酰基-1H-茚的硫代卡巴腙对痘苗病毒的抑制作用比用作参考标准的甲硫腙更大。此外，该化合物对副流感病毒和疱疹病毒也有活性。
