抗病毒化合物。十七 - 1-取代的2-氯-和2-甲氧基吲哚-3-甲醛硫代半卡巴腙的合成及体外抗病毒活性
Antiviral compounds. XVII - Synthesis and in vitro antiviral activity of 1-substituted 2-chloro- and 2-methoxyindole-3-carboxaldehyde thiosemicarbazones.
作者信息
Cavrini V, Gatti R, Giovanninetti G, Roveri P, Franchi L, Landini M P
出版信息
Farmaco Sci. 1981 Feb;36(2):140-5. doi: 10.1002/chin.198134211.
PMID:6262104
Abstract
A series of indole-3-carboxaldehyde thiosemicarbazones with substituent variations at the 1 and 2 positions were prepared and evaluated for in vitro antiviral activity against vaccinia virus strain IHD and parainfluenza virus type 3, HA-I/CR-8 strain. The inhibitory activity of most compounds was restricted to the vaccinia virus, only compounds (III e) and (III f) being effective against both viruses. Structure-activity relationship are discussed.
摘要
制备了一系列在1位和2位带有取代基变化的吲哚-3-甲醛缩氨基硫脲，并对其针对痘苗病毒IHD株和3型副流感病毒HA-I/CR-8株的体外抗病毒活性进行了评估。大多数化合物的抑制活性仅限于痘苗病毒，只有化合物（III e）和（III f）对两种病毒均有效。讨论了构效关系。
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