Mintz L, Drew W L, Hoo R, Finley T N
Infect Immun. 1980 May;28(2):417-20. doi: 10.1128/iai.28.2.417-420.1980.
Studies in mice demonstrate an age-dependent susceptibility to disseminated herpesvirus infection which is mediated. at least in part, by a defect in macrophage antiviral function. We examined the growth of herpes simplex virus within human alveolar macrophages obtained by bronchopulmonary lavage from neonates, adults with a variety of immunosuppressive disorders, and healthy adult volunteers. At 24 h postinfection, mean viral titers in neonatal macrophages increased 19-fold over adsorbed virus levels, a highly significant increase when compared to either immunosuppressed or normal adult macrophages (P less than 0.0005). These findings indicate that human macrophages, like those of mice, exhibit age-dependent permissiveness for the replication of herpes simplex virus. This permissiveness may at least partially account for the clinical observation that human newborns are highly susceptible to disseminated herpes simplex virus infections, whereas adults are not.
对小鼠的研究表明，其对播散性疱疹病毒感染的易感性存在年龄依赖性，这种易感性至少部分是由巨噬细胞抗病毒功能缺陷介导的。我们检测了单纯疱疹病毒在通过支气管肺灌洗从新生儿、患有各种免疫抑制疾病的成年人以及健康成年志愿者获取的人肺泡巨噬细胞内的生长情况。感染后24小时，新生儿巨噬细胞中的平均病毒滴度比吸附病毒水平增加了19倍，与免疫抑制或正常成年巨噬细胞相比，这是一个高度显著的增加（P小于0.0005）。这些发现表明，人类巨噬细胞与小鼠巨噬细胞一样，对单纯疱疹病毒的复制表现出年龄依赖性的易感性。这种易感性可能至少部分解释了临床观察结果，即人类新生儿对播散性单纯疱疹病毒感染高度易感，而成年人则不然。
