Bartosz G, Leyko W
Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Jan;39(1):39-46. doi: 10.1080/09553008114550051.
The effect of several free-radical scavengers on the radiation-induced haemolysis of bovine erythrocytes (50 krad, 60Co, cell concentration: 0.05 v/v) was studied. A two-phase effect of the additives was found with a maximum of the protective action in the millimolar concentration range. A correlation was established between the degree of protection at a fixed concentration (5mM) and the rate constants of reactions of respective compounds with OH. A radiosensitizing effect of diethyldithiocarbamate, an inhibitor of superoxide dismutase (SOD) was not confirmed and no specific protective effect of SOD was seen.
研究了几种自由基清除剂对牛红细胞辐射诱导溶血(50千拉德,60钴,细胞浓度:0.05 v/v)的影响。发现添加剂存在两相效应,在毫摩尔浓度范围内保护作用最大。确定了固定浓度(5毫摩尔)下的保护程度与各化合物与OH反应速率常数之间的相关性。未证实超氧化物歧化酶(SOD)抑制剂二乙基二硫代氨基甲酸盐的放射增敏作用,也未观察到SOD的特异性保护作用。