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牛红细胞对溶血的辐射防护作用。

Radioprotection of bovine erythrocytes to haemolysis.

作者信息

Bartosz G, Leyko W

出版信息

Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Jan;39(1):39-46. doi: 10.1080/09553008114550051.

DOI:10.1080/09553008114550051
PMID:6262260
Abstract

The effect of several free-radical scavengers on the radiation-induced haemolysis of bovine erythrocytes (50 krad, 60Co, cell concentration: 0.05 v/v) was studied. A two-phase effect of the additives was found with a maximum of the protective action in the millimolar concentration range. A correlation was established between the degree of protection at a fixed concentration (5mM) and the rate constants of reactions of respective compounds with OH. A radiosensitizing effect of diethyldithiocarbamate, an inhibitor of superoxide dismutase (SOD) was not confirmed and no specific protective effect of SOD was seen.

摘要

研究了几种自由基清除剂对牛红细胞辐射诱导溶血(50千拉德,60钴,细胞浓度:0.05 v/v)的影响。发现添加剂存在两相效应,在毫摩尔浓度范围内保护作用最大。确定了固定浓度(5毫摩尔)下的保护程度与各化合物与OH反应速率常数之间的相关性。未证实超氧化物歧化酶(SOD)抑制剂二乙基二硫代氨基甲酸盐的放射增敏作用,也未观察到SOD的特异性保护作用。

相似文献

1
Radioprotection of bovine erythrocytes to haemolysis.牛红细胞对溶血的辐射防护作用。
Int J Radiat Biol Relat Stud Phys Chem Med. 1981 Jan;39(1):39-46. doi: 10.1080/09553008114550051.
2
Effect of .OH scavengers on radiation damage to the erythrocyte membrane.羟自由基清除剂对红细胞膜辐射损伤的影响。
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Action of some hydroxyl radical scavengers on radiation-induced haemolysis.某些羟自由基清除剂对辐射诱导溶血的作用。
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Superoxide dismutase and radiation-induced haemolysis: no benefit of its increased content in red cells.超氧化物歧化酶与辐射诱导的溶血:红细胞中其含量增加并无益处。
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Radiosensitization of human erythrocytes by diethyldithiocarbamate.二乙氨基二硫代甲酸盐对人红细胞的放射增敏作用。
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引用本文的文献

1
Heavy ion induced membrane damage: hemolysis of erythrocytes and changes in erythrocyte membrane fluidity.重离子诱导的膜损伤:红细胞溶血及红细胞膜流动性的变化。
Radiat Environ Biophys. 1994;33(3):233-41. doi: 10.1007/BF01212679.
2
Lipid peroxidation and haemoglobin degradation in red blood cells exposed to t-butyl hydroperoxide. The relative roles of haem- and glutathione-dependent decomposition of t-butyl hydroperoxide and membrane lipid hydroperoxides in lipid peroxidation and haemolysis.暴露于叔丁基过氧化氢的红细胞中的脂质过氧化和血红蛋白降解。叔丁基过氧化氢和膜脂质氢过氧化物的血红素依赖性和谷胱甘肽依赖性分解在脂质过氧化和溶血中的相对作用。
Biochem J. 1983 Jun 15;212(3):759-72. doi: 10.1042/bj2120759.
3
Ionizing radiation-induced structural modification of human red blood cells.
电离辐射诱导的人类红细胞结构改变。
Radiat Environ Biophys. 1991;30(1):45-52. doi: 10.1007/BF01595573.