Dasgupta A, Chatterjee R, Chowdhury J R
Oncology. 1981;38(4):249-53. doi: 10.1159/000225560.
Out of 56 thioacetamide (TAA)-fed rats hepatocellular carcinoma were found in four instances after 300, 360, 450 and 495 days in the present experiment. Of the four tumours, two showed lung metastasis. The size of TAA-treated hepatocyte nucleoli increased greatly after several weeks of feeding. Two enzymes, succinate dehydrogenase and glucose-6-phosphatase were found in both cytoplasma and nucleoli of hepatocytes of which nucleolar localizations are quite new. In hepatocellular carcinoma, malignant cells lost glucose-6-phosphatase activity completely in cytoplasm and nucleoli though succinate dehydrogenase activity was present in these organelles.
在本实验中，56只喂食硫代乙酰胺（TAA）的大鼠中，分别在300、360、450和495天后发现了4例肝细胞癌。在这4个肿瘤中，有2个出现了肺转移。喂食TAA几周后，处理过的肝细胞核仁大小大幅增加。在肝细胞的细胞质和核仁中均发现了两种酶，即琥珀酸脱氢酶和葡萄糖-6-磷酸酶，其中核仁定位是相当新的发现。在肝细胞癌中，恶性细胞的细胞质和核仁中完全丧失了葡萄糖-6-磷酸酶活性，尽管这些细胞器中仍存在琥珀酸脱氢酶活性。
