Wong-Staal F, Dalla-Favera R, Franchini G, Gelmann E P, Gallo R C
Science. 1981 Jul 10;213(4504):226-8. doi: 10.1126/science.6264598.
Southern blot hybridization was used to identify human and other vertebrate DNA sequences that were homologous to cloned DNA fragments containing the oncogenic nucleic acid sequences of three different type C mammalian retroviruses (simian sarcoma virus, the Snyder-Theilen strain of feline sarcoma virus, and the Harvey strain of murine sarcoma virus). Each onc gene counterpart has a single genetic locus, which probably contains non-onc intervening sequences. The human DNA sequences may represent genes important to cell growth or cell differentiation, or both. Their identification and isolation may allow elucidation of their role in these processes and in neoplasias.
采用Southern印迹杂交法来鉴定与含有三种不同类型C型哺乳动物逆转录病毒（猿猴肉瘤病毒、猫肉瘤病毒的斯奈德-泰伦毒株和鼠肉瘤病毒的哈维毒株）致癌核酸序列的克隆DNA片段同源的人类及其他脊椎动物DNA序列。每个癌基因对应物都有一个单一的基因座，其中可能包含非癌间隔序列。这些人类DNA序列可能代表对细胞生长或细胞分化或两者都很重要的基因。对它们的鉴定和分离可能有助于阐明它们在这些过程以及肿瘤形成中的作用。
