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与斯奈德-泰伦猫肉瘤病毒致癌序列相关的人类基因(c-fes)。

Human gene (c-fes) related to the onc sequences of Snyder-Theilen feline sarcoma virus.

作者信息

Franchini G, Gelmann E P, Dalla-Favera R, Gallo R C, Wong-Staal F

出版信息

Mol Cell Biol. 1982 Aug;2(8):1014-9. doi: 10.1128/mcb.2.8.1014-1019.1982.

DOI:10.1128/mcb.2.8.1014-1019.1982
PMID:6290870
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC369889/
Abstract

The onc gene (v-fes) of the acutely transforming feline sarcoma virus (Snyder-Theilen strain) has homologous cellular sequences (c-fes) in all vertebrate species, including humans. We isolated from a human DNA library recombinant phages containing overlapping c-fes sequences. The human c-fes locus spans a region of 3.4 kilobases and contains 1.4 kilobases of DNA homologous to the viral onc sequence interspersed with three intervening sequences.

摘要

急性转化型猫肉瘤病毒(斯奈德-泰伦毒株)的癌基因(v-fes)在包括人类在内的所有脊椎动物物种中都有同源细胞序列(c-fes)。我们从人类DNA文库中分离出了含有重叠c-fes序列的重组噬菌体。人类c-fes基因座跨度为3.4千碱基,包含1.4千碱基与病毒癌基因序列同源的DNA,其间穿插着三个间隔序列。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2856/369889/8d7d9efa96aa/molcellb00120-0145-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2856/369889/e65010fa8719/molcellb00120-0143-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2856/369889/7be4cc3316bf/molcellb00120-0143-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2856/369889/8d7d9efa96aa/molcellb00120-0145-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2856/369889/e65010fa8719/molcellb00120-0143-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2856/369889/7be4cc3316bf/molcellb00120-0143-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2856/369889/8d7d9efa96aa/molcellb00120-0145-a.jpg

相似文献

1
Human gene (c-fes) related to the onc sequences of Snyder-Theilen feline sarcoma virus.与斯奈德-泰伦猫肉瘤病毒致癌序列相关的人类基因(c-fes)。
Mol Cell Biol. 1982 Aug;2(8):1014-9. doi: 10.1128/mcb.2.8.1014-1019.1982.
2
onc sequences (v-fes) of Snyder-Theilen feline sarcoma virus are derived from noncontiguous regions of a cat cellular gene (c-fes).斯奈德-泰伦猫肉瘤病毒的癌基因序列(v-fes)源自猫细胞基因(c-fes)的非连续区域。
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引用本文的文献

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2
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3
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本文引用的文献

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Markedly elevated levels of an endogenous sarc protein in a hemopoietic precursor cell line.造血前体细胞系中内源性肉瘤蛋白水平显著升高。
Mol Cell Biol. 1981 Jan;1(1):66-74. doi: 10.1128/mcb.1.1.66-74.1981.
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Recombinant bacteriophages containing the integrated transforming provirus of Gardner--Arnstein feline sarcoma virus.含有整合型加德纳-阿恩斯坦猫肉瘤病毒转化前病毒的重组噬菌体。
Proc Natl Acad Sci U S A. 1981 Jul;78(7):4036-40. doi: 10.1073/pnas.78.7.4036.
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The human c-fps/fes gene product expressed ectopically in rat fibroblasts is nontransforming and has restrained protein-tyrosine kinase activity.在大鼠成纤维细胞中异位表达的人c-fps/fes基因产物无转化能力,且其蛋白酪氨酸激酶活性受到抑制。
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一种与猿猴肉瘤病毒的转化基因(v-sis)同源的人类癌基因。
Nature. 1981 Jul 2;292(5818):31-5. doi: 10.1038/292031a0.
4
Three distinct genes in human DNA related to the transforming genes of mammalian sarcoma retroviruses.人类DNA中与哺乳动物肉瘤逆转录病毒的转化基因相关的三个不同基因。
Science. 1981 Jul 10;213(4504):226-8. doi: 10.1126/science.6264598.
5
Evidence for three classes of avian sarcoma viruses: comparison of the transformation-specific proteins of PRCII, Y73, and Fujinami viruses.三类禽肉瘤病毒的证据:PRCII、Y73和 Fujinami 病毒转化特异性蛋白的比较。
Proc Natl Acad Sci U S A. 1981 Mar;78(3):1906-10. doi: 10.1073/pnas.78.3.1906.
6
onc sequences (v-fes) of Snyder-Theilen feline sarcoma virus are derived from noncontiguous regions of a cat cellular gene (c-fes).斯奈德-泰伦猫肉瘤病毒的癌基因序列(v-fes)源自猫细胞基因(c-fes)的非连续区域。
Nature. 1981 Mar 12;290(5802):154-7. doi: 10.1038/290154a0.
7
Homology exists among the transforming sequences of avian and feline sarcoma viruses.禽肉瘤病毒和猫肉瘤病毒的转化序列之间存在同源性。
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6536-40. doi: 10.1073/pnas.77.11.6536.
8
Origin and functional properties of the major gene product of the Snyder-Theilen strain of feline sarcoma virus.猫肉瘤病毒斯奈德-泰伦毒株主要基因产物的起源及功能特性
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9
Three independent isolates of feline sarcoma virus code for three distinct gag-x polyproteins.猫肉瘤病毒的三个独立分离株编码三种不同的gag-x多蛋白。
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10
Feline sarcoma virus polyprotein P115 binds a host phosphoprotein in transformed cells.猫肉瘤病毒多聚蛋白P115在转化细胞中与一种宿主磷蛋白结合。
Nature. 1980 Jul 24;286(5771):409-12. doi: 10.1038/286409a0.