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人血清中Bay n 7133的高压液相色谱测定法

High-pressure liquid chromatographic assay of Bay n 7133 in human serum.

作者信息

Fasching C E, Hughes C E, Hector R F, Peterson L R

出版信息

Antimicrob Agents Chemother. 1984 May;25(5):596-8. doi: 10.1128/AAC.25.5.596.

DOI:10.1128/AAC.25.5.596
PMID:6375561
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC185594/
Abstract

A high-pressure liquid chromatographic method that includes a Sep-Pak (Waters Associates, Inc., Milford , Mass.) preparation of human serum was employed for the quantitative assay of Bay n 7133. Drug levels of 0.1 to 20 micrograms/ml could be detected. No interference from amphotericin B was found in the chromatographic analysis of Bay n 7133.

摘要

采用一种高压液相色谱法,该方法包括用人血清进行Sep - Pak( Waters Associates公司,马萨诸塞州米尔福德)预处理,用于定量测定Bay n 7133。可检测到0.1至20微克/毫升的药物水平。在Bay n 7133的色谱分析中未发现两性霉素B的干扰。

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本文引用的文献

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Antimicrob Agents Chemother. 1981 Jul;20(1):59-62. doi: 10.1128/AAC.20.1.59.
2
Liquid chromatographic assay of ketoconazole.酮康唑的液相色谱测定法。
Antimicrob Agents Chemother. 1981 Jan;19(1):110-3. doi: 10.1128/AAC.19.1.110.
3
Improved procedure for the determination of the ureidopenicillins azlocillin and mezlocillin plasma by high-performance liquid chromatography.
J Chromatogr. 1982 Mar 12;228:409-12. doi: 10.1016/s0378-4347(00)80464-8.
4
Quantitation of amphotericin B with use of high-pressure liquid chromatography.
J Infect Dis. 1977 Mar;135(3):414-22. doi: 10.1093/infdis/135.3.414.
5
Simple assay for 5-fluorocytosine in the presence of amphotericin B.在两性霉素B存在的情况下对5-氟胞嘧啶进行的简易检测
Antimicrob Agents Chemother. 1976 Mar;9(3):381-3. doi: 10.1128/AAC.9.3.381.
6
Rapid determination of serum 5-fluorocytosine levels by high-performance liquid chromatography.高效液相色谱法快速测定血清5-氟胞嘧啶水平
Antimicrob Agents Chemother. 1978 Mar;13(3):500-4. doi: 10.1128/AAC.13.3.500.