大肠杆菌和鼠伤寒沙门氏菌的supX基因可编码脱氧核糖核酸拓扑异构酶I。
Escherichia coli and Salmonella typhimurium supX genes specify deoxyribonucleic acid topoisomerase I.
作者信息
Trucksis M, Golub E I, Zabel D J, Depew R E
出版信息
J Bacteriol. 1981 Aug;147(2):679-81. doi: 10.1128/jb.147.2.679-681.1981.
Abstract
Mutations of the Escherichia coli or Salmonella typhimurium supX genes eliminated deoxyribonucleic acid topoisomerase I. Suppression of a supX amber mutation partially restored the topoisomerase. Multicopy plasmids carrying supX+ caused overproduction of topoisomerase. Thus, these supX genes were identified as topA genes which specify deoxyribonucleic acid topoisomerase I.
摘要
大肠杆菌或鼠伤寒沙门氏菌supX基因的突变消除了脱氧核糖核酸拓扑异构酶I。对supX琥珀突变的抑制部分恢复了拓扑异构酶。携带supX+的多拷贝质粒导致拓扑异构酶过量产生。因此，这些supX基因被鉴定为指定脱氧核糖核酸拓扑异构酶I的topA基因。
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