Gershon A A, Steinberg S P
Infect Immun. 1981 Aug;33(2):507-11. doi: 10.1128/iai.33.2.507-511.1981.
Inactivation of varicella zoster virus in vitro by nonadherent, mononuclear peripheral blood leukocytes and antibody is described. When leukocytes and specific antibody were incubated with this virus, marked inactivation of the virus occurred. In contrast, leukocytes alone or with serum devoid of varicella zoster antibody caused only a small degree of inactivation of varicella zoster virus. The leukocytes involved appeared not to be monocyte-macrophages or T or B lymphocytes, and only minute amounts of specific antibody were required. We had found previously that leukocytes from unsensitized (varicella susceptible) as well as sensitized (varicella immune) donors could cause this reaction. We therefore propose that the reaction may be a form of antibody-dependent cellular cytotoxicity, as has been described for 51Cr release by lymphoid (K) cells for other herpesviruses.
本文描述了非黏附性单核外周血白细胞和抗体在体外对水痘带状疱疹病毒的灭活作用。当白细胞和特异性抗体与该病毒一起孵育时，病毒会发生显著灭活。相比之下，单独的白细胞或与不含水痘带状疱疹抗体的血清一起时，仅会导致水痘带状疱疹病毒发生轻微程度的灭活。所涉及的白细胞似乎不是单核巨噬细胞或T或B淋巴细胞，并且仅需要微量的特异性抗体。我们之前发现，来自未致敏（对水痘易感）以及致敏（对水痘免疫）供体的白细胞均可引发这种反应。因此，我们提出这种反应可能是一种抗体依赖性细胞毒性形式，正如淋巴（K）细胞对其他疱疹病毒释放51Cr所描述的那样。
