Jager R M, Max M H
J Clin Gastroenterol. 1981 Mar;3(1):73-7. doi: 10.1097/00004836-198103000-00015.
We have seen a patient with a squamous carcinoma of the esophagus along with hepatocellular carcinoma. Though the simultaneous occurrence of these tumors is rare, we propose that their development may be more than a chance occurrence. Since many chemical carcinogens which promote esophageal cancers in experimental animals also promote hepatic malignancies, it is possible that dietary nitrosamines in man, causally implicated in esophageal carcinoma, may also sometimes induce hepatic carcinoma in the same patient.
我们见过一位患有食管鳞状细胞癌并伴有肝细胞癌的患者。虽然这些肿瘤同时出现的情况很少见，但我们认为它们的发生可能并非偶然。由于许多在实验动物中可诱发食管癌的化学致癌物也可诱发肝脏恶性肿瘤，因此，人类饮食中的亚硝胺与食管癌有因果关系，有时也可能在同一患者中诱发肝癌。
