Gurwith M, Wenman W, Hinde D, Feltham S, Greenberg H
J Infect Dis. 1981 Sep;144(3):218-24. doi: 10.1093/infdis/144.3.218.
Diarrhea in neonates, followed as a cohort, and their families was studied prospectively. The families were followed for an average of 16.3 months. Stool and serum specimens were obtained at least every three months. Stool specimens were examined for viruses by electron microscopy and cultured for enteropathogens, and serum specimens were tested for antibodies to rotavirus and Norwalk virus. During the study, 237 episodes of gastroenteritis were observed in 104 infants and their 62 siblings. Rotavirus, detected 82 times in 72 children, was by far the most common enteropathogen. It was associated with gastrointestinal symptoms in 72% (with diarrhea in 65%). Rotavirus diarrhea occurred mostly in winter months and was significantly more frequently associated with respiratory symptoms than were diarrheas with other etiologies. Rotavirus infection was uncommon in the first six months of life, but by two years of age, 62% of the infants had had at least one infection. Neither breast feeding nor the presence of antibody to rotavirus in cord blood appeared to be protective.
对新生儿及其家庭进行了前瞻性队列研究，观察新生儿腹泻情况。对这些家庭平均随访了16.3个月。至少每三个月采集一次粪便和血清样本。粪便样本通过电子显微镜检查病毒，并培养肠道病原体，血清样本检测轮状病毒和诺沃克病毒抗体。在研究期间，104名婴儿及其62名兄弟姐妹共发生237次肠胃炎发作。轮状病毒在72名儿童中被检测出82次，是迄今为止最常见的肠道病原体。它与72%的胃肠道症状相关（其中65%伴有腹泻）。轮状病毒腹泻大多发生在冬季，与其他病因引起的腹泻相比，与呼吸道症状的关联更为显著。轮状病毒感染在出生后的前六个月并不常见，但到两岁时，62%的婴儿至少感染过一次。母乳喂养和脐带血中轮状病毒抗体的存在似乎都没有保护作用。
