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头孢哌酮与CP-45,899对产β-内酰胺酶的流感嗜血杆菌大量接种物的杀菌活性。

Bactericidal activity of cefoperazone with CP-45,899 against large inocula of beta-lactamase-producing Haemophilus influenzae.

作者信息

Yu P K, Washington J A

出版信息

Antimicrob Agents Chemother. 1981 Jul;20(1):63-5. doi: 10.1128/AAC.20.1.63.

DOI:10.1128/AAC.20.1.63
PMID:6269484
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC181633/
Abstract

Bactericidal activity of cefoperazone, alone and in combination with the beta-lactamase inhibitor CP-45,899, was tested against inocula of 10(7) colony-forming units of beta-lactamase-producing isolates of Haemophilus influenzae type b per ml. Of 19 strains tested, 10 required greater than or equal to 64 microgram of cefoperazone per ml for killing, whereas no strains were killed by less than 64 microgram of CP-45,899 per ml. Synergy occurred with the combination of 4 microgram of each agent per ml against 9 of the 10 cefoperazone-resistant strains.

摘要

针对每毫升含10⁷个产β-内酰胺酶的b型流感嗜血杆菌分离株菌落形成单位的接种物，测试了头孢哌酮单独及与β-内酰胺酶抑制剂CP-45899联合使用时的杀菌活性。在测试的19株菌株中，10株需要每毫升大于或等于64微克的头孢哌酮才能被杀死，而每毫升低于64微克的CP-45899不能杀死任何菌株。每毫升4微克的两种药物联合使用时，对10株头孢哌酮耐药菌株中的9株产生了协同作用。

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Bactericidal activity of cefoperazone with CP-45,899 against large inocula of beta-lactamase-producing Haemophilus influenzae.头孢哌酮与CP-45,899对产β-内酰胺酶的流感嗜血杆菌大量接种物的杀菌活性。
Antimicrob Agents Chemother. 1981 Jul;20(1):63-5. doi: 10.1128/AAC.20.1.63.
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本文引用的文献

1
Comparison of cefamandole, cephalothin, ampicillin, and chloramphenicol in experimental Escherichia coli meningitis.头孢孟多、头孢噻吩、氨苄西林和氯霉素在实验性大肠杆菌脑膜炎中的比较。
Antimicrob Agents Chemother. 1980 Jan;17(1):37-42. doi: 10.1128/AAC.17.1.37.
2
Effect of inoculum size and beta-lactamase production on in vitro activity of new cephalosporins against Haemophilus species.接种量和β-内酰胺酶产生对新型头孢菌素体外抗嗜血杆菌属活性的影响。
Antimicrob Agents Chemother. 1980 Mar;17(3):393-6. doi: 10.1128/AAC.17.3.393.
3
In vitro and in vivo antibacterial activity of cefoperazone.头孢哌酮的体外和体内抗菌活性。
Clin Ther. 1980;3(Spec Issue):1-13.
4
In vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase-producing strains.头孢哌酮、头孢噻肟、拉氧头孢（LY127935）、阿洛西林、美洛西林及其他β-内酰胺类抗生素对淋病奈瑟菌和流感嗜血杆菌的体外抗菌活性，包括产β-内酰胺酶菌株。
Antimicrob Agents Chemother. 1980 Apr;17(4):757-61. doi: 10.1128/AAC.17.4.757.
5
CP-45,899 in combination with penicillin or ampicillin against penicillin-resistant Staphylococcus, Haemophilus influenzae, and Bacteroides.CP - 45,899与青霉素或氨苄青霉素联合用于对抗耐青霉素的葡萄球菌、流感嗜血杆菌和拟杆菌。
Antimicrob Agents Chemother. 1980 Apr;17(4):615-22. doi: 10.1128/AAC.17.4.615.
6
Clavulanic acid and CP-45,899: a comparison of their in vitro activity in combination with penicillins.克拉维酸与CP-45,899：二者与青霉素联合应用的体外活性比较
J Antimicrob Chemother. 1980 Mar;6(2):197-206. doi: 10.1093/jac/6.2.197.
7
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Antimicrob Agents Chemother. 1975 Jul;8(1):91-4. doi: 10.1128/AAC.8.1.91.
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J Pediatr. 1975 Apr;86(4):617-20. doi: 10.1016/s0022-3476(75)80166-1.
9
In vitro comparison of cefoxitin, cefamandole, cephalexin, and cephalothin.头孢西丁、头孢孟多、头孢氨苄和头孢噻吩的体外比较
Antimicrob Agents Chemother. 1976 Jun;9(6):994-9. doi: 10.1128/AAC.9.6.994.
10
The beta-lactamases of gram-negative bacteria and their role in resistance to beta-lactam antibiotics.革兰氏阴性菌的β-内酰胺酶及其在对β-内酰胺类抗生素耐药性中的作用。
J Antimicrob Chemother. 1976 Jun;2(2):115-57. doi: 10.1093/jac/2.2.115.