头孢哌酮与CP-45,899对产β-内酰胺酶的流感嗜血杆菌大量接种物的杀菌活性。
Bactericidal activity of cefoperazone with CP-45,899 against large inocula of beta-lactamase-producing Haemophilus influenzae.
作者信息
Yu P K, Washington J A
出版信息
Antimicrob Agents Chemother. 1981 Jul;20(1):63-5. doi: 10.1128/AAC.20.1.63.
Abstract
Bactericidal activity of cefoperazone, alone and in combination with the beta-lactamase inhibitor CP-45,899, was tested against inocula of 10(7) colony-forming units of beta-lactamase-producing isolates of Haemophilus influenzae type b per ml. Of 19 strains tested, 10 required greater than or equal to 64 microgram of cefoperazone per ml for killing, whereas no strains were killed by less than 64 microgram of CP-45,899 per ml. Synergy occurred with the combination of 4 microgram of each agent per ml against 9 of the 10 cefoperazone-resistant strains.
摘要
针对每毫升含10⁷个产β-内酰胺酶的b型流感嗜血杆菌分离株菌落形成单位的接种物，测试了头孢哌酮单独及与β-内酰胺酶抑制剂CP-45899联合使用时的杀菌活性。在测试的19株菌株中，10株需要每毫升大于或等于64微克的头孢哌酮才能被杀死，而每毫升低于64微克的CP-45899不能杀死任何菌株。每毫升4微克的两种药物联合使用时，对10株头孢哌酮耐药菌株中的9株产生了协同作用。
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