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接种量和β-内酰胺酶产生对新型头孢菌素体外抗嗜血杆菌属活性的影响。

Effect of inoculum size and beta-lactamase production on in vitro activity of new cephalosporins against Haemophilus species.

作者信息

Bulger R R, Washington J A

出版信息

Antimicrob Agents Chemother. 1980 Mar;17(3):393-6. doi: 10.1128/AAC.17.3.393.

DOI:10.1128/AAC.17.3.393
PMID:6448575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC283797/
Abstract

Sixty-three strains of Haemophilus species, 38 of which were beta-lactamase producers (37 H. influenzae type b, 1 H. parainfluenzae) and 25 of which were beta-lactamase negative (20 H. influenzae, 5 H. parainfluenzae), were tested for susceptibility to cefoxitin, moxalactam (LY127935) (Lilly), cefsulodin (CGP 7174 E, Ciba), and cefoperazone (T 1551, Pfizer). Cefsulodin was relatively inactive at both low and high inocula. LY127935 and cefoperazone displayed inoculum-dependent bactericidal activity. Cefoxitin displayed little inoculum effect against beta-lactamase-producing strains: 8 and 16 microgram/ml killed at least 90% of those tested at 10(4) and 10(6) colony-forming units per ml, respectively.

摘要

对63株嗜血杆菌进行了头孢西丁、莫拉司亭（LY127935，礼来公司）、头孢磺啶（CGP 7174 E，汽巴公司）和头孢哌酮（T 1551，辉瑞公司）的药敏试验，其中38株产β-内酰胺酶（37株b型流感嗜血杆菌，1株副流感嗜血杆菌），25株β-内酰胺酶阴性（20株流感嗜血杆菌，5株副流感嗜血杆菌）。头孢磺啶在低接种量和高接种量时活性都相对较低。LY127935和头孢哌酮表现出接种量依赖性杀菌活性。头孢西丁对产β-内酰胺酶菌株几乎没有接种量效应：每毫升分别含10⁴和10⁶个菌落形成单位时，8微克/毫升和16微克/毫升的头孢西丁分别杀死了至少90%的受试菌株。

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Effect of inoculum size and beta-lactamase production on in vitro activity of new cephalosporins against Haemophilus species.接种量和β-内酰胺酶产生对新型头孢菌素体外抗嗜血杆菌属活性的影响。
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本文引用的文献

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Antimicrob Agents Chemother. 1974 Nov;6(5):620-4. doi: 10.1128/AAC.6.5.620.
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The in vitro sensitivity of Haemophilus influenzae to clindamycin.流感嗜血杆菌对克林霉素的体外敏感性
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Susceptibility of ampicillin-resistant Haemophilus influenzae to seven penicillins.耐氨苄西林流感嗜血杆菌对七种青霉素的敏感性
Antimicrob Agents Chemother. 1976 Jan;9(1):70-3. doi: 10.1128/AAC.9.1.70.
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Spurious ampicillin resistance by testing Haemophilus influenzae with agar containing supplement C.通过使用含补充剂C的琼脂检测流感嗜血杆菌而产生的假性氨苄西林耐药性。
Antimicrob Agents Chemother. 1976 Jan;9(1):199-200. doi: 10.1128/AAC.9.1.199.
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Antimicrob Agents Chemother. 1975 Jul;8(1):91-4. doi: 10.1128/AAC.8.1.91.
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Simplified medium for ampicillin susceptibility testing of Haemophilus influenzae.流感嗜血杆菌氨苄西林药敏试验的简化培养基。
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Hemophilus influenzae type B susceptibility to 17 antibiotics.B型流感嗜血杆菌对17种抗生素的敏感性
J Pediatr. 1975 Apr;86(4):617-20. doi: 10.1016/s0022-3476(75)80166-1.
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In vitro comparison of cefoxitin, cefamandole, cephalexin, and cephalothin.头孢西丁、头孢孟多、头孢氨苄和头孢噻吩的体外比较
Antimicrob Agents Chemother. 1976 Jun;9(6):994-9. doi: 10.1128/AAC.9.6.994.
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A rapid slide test for penicillinase.一种用于青霉素酶的快速玻片试验。
Am J Clin Pathol. 1978 Mar;69(3):351-4. doi: 10.1093/ajcp/69.1.351.
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Antimicrob Agents Chemother. 1979 Oct;16(4):510-3. doi: 10.1128/AAC.16.4.510.