接种量和β-内酰胺酶产生对新型头孢菌素体外抗嗜血杆菌属活性的影响。
Effect of inoculum size and beta-lactamase production on in vitro activity of new cephalosporins against Haemophilus species.
作者信息
Bulger R R, Washington J A
出版信息
Antimicrob Agents Chemother. 1980 Mar;17(3):393-6. doi: 10.1128/AAC.17.3.393.
Abstract
Sixty-three strains of Haemophilus species, 38 of which were beta-lactamase producers (37 H. influenzae type b, 1 H. parainfluenzae) and 25 of which were beta-lactamase negative (20 H. influenzae, 5 H. parainfluenzae), were tested for susceptibility to cefoxitin, moxalactam (LY127935) (Lilly), cefsulodin (CGP 7174 E, Ciba), and cefoperazone (T 1551, Pfizer). Cefsulodin was relatively inactive at both low and high inocula. LY127935 and cefoperazone displayed inoculum-dependent bactericidal activity. Cefoxitin displayed little inoculum effect against beta-lactamase-producing strains: 8 and 16 microgram/ml killed at least 90% of those tested at 10(4) and 10(6) colony-forming units per ml, respectively.
摘要
对63株嗜血杆菌进行了头孢西丁、莫拉司亭（LY127935，礼来公司）、头孢磺啶（CGP 7174 E，汽巴公司）和头孢哌酮（T 1551，辉瑞公司）的药敏试验，其中38株产β-内酰胺酶（37株b型流感嗜血杆菌，1株副流感嗜血杆菌），25株β-内酰胺酶阴性（20株流感嗜血杆菌，5株副流感嗜血杆菌）。头孢磺啶在低接种量和高接种量时活性都相对较低。LY127935和头孢哌酮表现出接种量依赖性杀菌活性。头孢西丁对产β-内酰胺酶菌株几乎没有接种量效应：每毫升分别含10⁴和10⁶个菌落形成单位时，8微克/毫升和16微克/毫升的头孢西丁分别杀死了至少90%的受试菌株。
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Effect of inoculum size and beta-lactamase production on in vitro activity of new cephalosporins against Haemophilus species.接种量和β-内酰胺酶产生对新型头孢菌素体外抗嗜血杆菌属活性的影响。
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