接种量对b型流感嗜血杆菌对新型和传统抗生素敏感性的影响。
Effect of inoculum size on Haemophilus influenzae type b susceptibility to new and conventional antibiotics.
作者信息
Laferriere C, Marks M I, Welch D F
出版信息
Antimicrob Agents Chemother. 1983 Aug;24(2):287-9. doi: 10.1128/AAC.24.2.287.
Abstract
Thirty-three Haemophilus influenzae type b isolates, including beta-lactamase acetyltransferase-positive strains, were tested by microtiter broth dilution for susceptibility to eight beta-lactam compounds and chloramphenicol. All antibiotics except ampicillin and chloramphenicol were highly bactericidal against all isolates at an inoculum of 10(5) CFU/ml. However, at an inoculum of 10(5) CFU/ml, the minimal bactericidal concentrations of all drugs except ceftriaxone were above levels usually achievable in cerebrospinal fluid. Results of time-kill studies confirmed this inoculum effect. In vivo studies are needed to test the clinical impact of these observations.
摘要
对33株b型流感嗜血杆菌分离株，包括β-内酰胺酶乙酰转移酶阳性菌株，采用微量肉汤稀释法检测其对8种β-内酰胺类化合物和氯霉素的敏感性。除氨苄西林和氯霉素外，所有抗生素在接种量为10(5) CFU/ml时对所有分离株均具有高度杀菌活性。然而，在接种量为10(5) CFU/ml时，除头孢曲松外，所有药物的最低杀菌浓度均高于脑脊液中通常可达到的水平。时间杀菌研究结果证实了这种接种量效应。需要进行体内研究以测试这些观察结果的临床影响。
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