接种量对b型流感嗜血杆菌对新型和传统抗生素敏感性的影响。
Effect of inoculum size on Haemophilus influenzae type b susceptibility to new and conventional antibiotics.
作者信息
Laferriere C, Marks M I, Welch D F
出版信息
Antimicrob Agents Chemother. 1983 Aug;24(2):287-9. doi: 10.1128/AAC.24.2.287.
Abstract
Thirty-three Haemophilus influenzae type b isolates, including beta-lactamase acetyltransferase-positive strains, were tested by microtiter broth dilution for susceptibility to eight beta-lactam compounds and chloramphenicol. All antibiotics except ampicillin and chloramphenicol were highly bactericidal against all isolates at an inoculum of 10(5) CFU/ml. However, at an inoculum of 10(5) CFU/ml, the minimal bactericidal concentrations of all drugs except ceftriaxone were above levels usually achievable in cerebrospinal fluid. Results of time-kill studies confirmed this inoculum effect. In vivo studies are needed to test the clinical impact of these observations.
摘要
对33株b型流感嗜血杆菌分离株，包括β-内酰胺酶乙酰转移酶阳性菌株，采用微量肉汤稀释法检测其对8种β-内酰胺类化合物和氯霉素的敏感性。除氨苄西林和氯霉素外，所有抗生素在接种量为10(5) CFU/ml时对所有分离株均具有高度杀菌活性。然而，在接种量为10(5) CFU/ml时，除头孢曲松外，所有药物的最低杀菌浓度均高于脑脊液中通常可达到的水平。时间杀菌研究结果证实了这种接种量效应。需要进行体内研究以测试这些观察结果的临床影响。
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本文引用的文献
1
Susceptibility of Hemophilus influenzae to 21 antibiotics in vitro.
Am J Med Sci. 1960 Jan;239:33-40. doi: 10.1097/00000441-196001000-00005.
2
Treatment of purulent meningitis with a new cephalosporin-Rocephin (Ro 13-9904). Clinical, bacteriological and pharmacological observations in 24 cases.
Chemotherapy. 1981;27 Suppl 1:57-61. doi: 10.1159/000238030.
3
Relation of concentrations of Haemophilus influenzae type b in cerebrospinal fluid to late sequelae of patients with meningitis.
J Pediatr. 1982 Feb;100(2):209-12. doi: 10.1016/s0022-3476(82)80636-7.
4
Susceptibility of Haemophilus influenzae type b to cefaclor and influence of inoculum size.
Antimicrob Agents Chemother. 1982 Nov;22(5):923-5. doi: 10.1128/AAC.22.5.923.
5
Effect of inoculum size and beta-lactamase production on in vitro activity of new cephalosporins against Haemophilus species.
Antimicrob Agents Chemother. 1980 Mar;17(3):393-6. doi: 10.1128/AAC.17.3.393.
6
Ceftriaxone diffusion into cerebrospinal fluid of children with meningitis.
Antimicrob Agents Chemother. 1983 Jan;23(1):46-8. doi: 10.1128/AAC.23.1.46.
7
Inoculum size effect on the MIC of cefoperazone, moxalactam, cefotaxime, cefoxitin and cephalothin for 118 strains of Haemophilus influenzae including 'tolerant' micro-organisms.
J Antimicrob Chemother. 1982 Nov;10(5):397-402. doi: 10.1093/jac/10.5.397.
8
Bactericidal activity of cefoperazone with CP-45,899 against large inocula of beta-lactamase-producing Haemophilus influenzae.
Antimicrob Agents Chemother. 1981 Jul;20(1):63-5. doi: 10.1128/AAC.20.1.63.
9
Antimicrobial susceptibility of Hemophilus influenzae.
Pediatrics. 1970 May;45(5):827-38.
10
Effect of inoculum size on the susceptibility of Haemophilus influenzae b to beta-lactam antibiotics.
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