水痘带状疱疹病毒疫苗DNA与亲代病毒DNA不同。
Varicella-zoster virus vaccine DNA differs from the parental virus DNA.
作者信息
Ecker J R, Hyman R W
出版信息
J Virol. 1981 Oct;40(1):314-8. doi: 10.1128/JVI.40.1.314-318.1981.
Abstract
The DNAs of a varicella-zoster virus vaccine and its parental virus were compared by CsCl buoyant density centrifugation and restriction enzyme cleavage analysis. The varicella-zoster virus vaccine DNA showed a heterogeneous buoyant profile and altered restriction enzyme cleavage patterns. These changed properties are probably the result of the accumulation of virus containing defective varicella-zoster virus DNA during extensive cell culture passage of the vaccine virus.
摘要
通过氯化铯浮力密度离心和限制性内切酶切割分析，对水痘-带状疱疹病毒疫苗及其亲本病毒的DNA进行了比较。水痘-带状疱疹病毒疫苗DNA呈现出异质的浮力图谱，并改变了限制性内切酶切割模式。这些变化的特性可能是疫苗病毒在广泛的细胞培养传代过程中，含有缺陷水痘-带状疱疹病毒DNA的病毒积累的结果。
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