水痘-带状疱疹疫苗病毒和野生型DNA的限制性内切酶分析。
Restriction endonuclease analysis of varicella-zoster vaccine virus and wild-type DNAs.
作者信息
Martin J H, Dohner D E, Wellinghoff W J, Gelb L D
出版信息
J Med Virol. 1982;9(1):69-76. doi: 10.1002/jmv.1890090110.
PMID:6278073
Abstract
The DNA from several clinical isolates of varicella-zoster virus (VZV) were compared with the DNA from the vaccine strain VZV using three restriction endonucleases: BamHI, BgII, and HpaI. When electrophoresed through an agarose gel, the vaccine DNA digestion pattern was significantly different from the digestion patterns of the wild-type DNAs. Variations in the digestion pattern of the separate clinical isolates were also observed.
摘要
使用三种限制性内切酶（BamHI、BgII和HpaI），将水痘带状疱疹病毒（VZV）几种临床分离株的DNA与疫苗株VZV的DNA进行比较。当通过琼脂糖凝胶进行电泳时，疫苗DNA的消化模式与野生型DNA的消化模式显著不同。还观察到各个临床分离株消化模式的差异。
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