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肺内皮细胞上的Fc和C3b受体:损伤诱导作用。

Fc and C3b receptors on pulmonary endothelial cells: induction by injury.

作者信息

Ryan U S, Schultz D R, Ruan J W

出版信息

Science. 1981 Oct 30;214(4520):557-8. doi: 10.1126/science.6270789.

DOI:10.1126/science.6270789
PMID:6270789
Abstract

Receptors for the activated third component of complement and for the Fc portion of immunoglobulin G are not expressed by apparently normal bovine pulmonary endothelial cells, but are expressed when the cells are exposed to white cell lysates or are infected with influenza or cytomegalovirus. The unmasking of these latent receptors may contribute to the pulmonary inflammatory response characteristic of, for example, anaphylaxis and to those lung diseases characterized by the deposition of immune complexes.

摘要

补体激活的第三成分受体和免疫球蛋白G的Fc段受体在外观正常的牛肺内皮细胞中不表达,但当细胞暴露于白细胞裂解物或感染流感病毒或巨细胞病毒时会表达。这些潜在受体的暴露可能导致例如过敏反应所特有的肺部炎症反应,以及那些以免疫复合物沉积为特征的肺部疾病。

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1
Fc and C3b receptors on pulmonary endothelial cells: induction by injury.肺内皮细胞上的Fc和C3b受体:损伤诱导作用。
Science. 1981 Oct 30;214(4520):557-8. doi: 10.1126/science.6270789.
2
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Inflammation. 2002 Jun;26(3):103-10. doi: 10.1023/a:1015585530204.
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Detection of Fcgamma receptors on human endothelial cells stimulated with cytokines tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma).
检测用细胞因子肿瘤坏死因子-α(TNF-α)和干扰素-γ(IFN-γ)刺激的人内皮细胞上的Fcγ受体。
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Combinations of low concentrations of cytokines and acute agonists synergize in increasing the permeability of endothelial monolayers.低浓度细胞因子与急性激动剂联合使用可协同增加内皮细胞单层的通透性。
Clin Exp Immunol. 1993 Feb;91(2):314-9. doi: 10.1111/j.1365-2249.1993.tb05901.x.
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