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牛肺动脉内皮细胞缺乏C3b受体和免疫球蛋白G的Fc段受体。

Endothelial cells of bovine pulmonary artery lack receptors for C3b and for the Fc portion of immunoglobulin G.

作者信息

Ryan U S, Schultz D R, Del Vecchio P J, Ryan J W

出版信息

Science. 1980 May 16;208(4445):748-9. doi: 10.1126/science.7367890.

DOI:10.1126/science.7367890
PMID:7367890
Abstract

Bovine pulmonary endothelial cells do not possess receptors for the 3b component of complement (C3b) or for the Fc portion of immunoglobulin G. The lack of these receptors may help explain the nonthrombogenic function of endothelial cells. Our findings rule out the possibility that endothelial cells participate in pulmonary immune complex disease through the binding of C3b or Fc fragments.

摘要

牛肺内皮细胞不具备补体3b成分（C3b）的受体，也不具备免疫球蛋白G的Fc部分的受体。这些受体的缺乏可能有助于解释内皮细胞的抗血栓形成功能。我们的研究结果排除了内皮细胞通过C3b或Fc片段的结合参与肺部免疫复合物疾病的可能性。

相似文献

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Endothelial cells of bovine pulmonary artery lack receptors for C3b and for the Fc portion of immunoglobulin G.牛肺动脉内皮细胞缺乏C3b受体和免疫球蛋白G的Fc段受体。
Science. 1980 May 16;208(4445):748-9. doi: 10.1126/science.7367890.
2
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引用本文的文献

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Identification of C1q as the heat-labile serum cofactor required for immune complexes to stimulate endothelial expression of the adhesion molecules E-selectin and intercellular and vascular cell adhesion molecules 1.鉴定C1q作为免疫复合物刺激内皮细胞表达黏附分子E-选择素、细胞间黏附分子1和血管细胞黏附分子1所需的热不稳定血清辅因子。
Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8378-82. doi: 10.1073/pnas.92.18.8378.
2
Fc and C3 receptors induced by herpes simplex virus on cultured human endothelial cells.单纯疱疹病毒在培养的人内皮细胞上诱导产生的Fc和C3受体
J Clin Invest. 1982 Jan;69(1):123-8. doi: 10.1172/jci110422.
3
Presence of complement-fixing anti-endothelial cell antibodies in systemic lupus erythematosus.
系统性红斑狼疮中补体结合抗内皮细胞抗体的存在。
J Clin Invest. 1984 Mar;73(3):611-25. doi: 10.1172/JCI111251.
4
Isolation and culture of pulmonary endothelial cells.肺内皮细胞的分离与培养。
Environ Health Perspect. 1984 Jun;56:103-14. doi: 10.1289/ehp.8456103.
5
Determination of human factor VIII (AHG-associated protein)--antigen in endothelial cells from Xenopus laevis (XTH cells). Evaluation of a sensitive ELISA technique.
Cell Tissue Res. 1986;245(2):445-51. doi: 10.1007/BF00213953.
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Heat-induced aggregated human IgG modifies the adherence of human polymorphonuclear cells to cultured endothelium.热诱导聚集的人免疫球蛋白G改变人多形核细胞对培养内皮细胞的黏附。
Clin Exp Immunol. 1989 Sep;77(3):356-60.
7
C1q binding to human vascular smooth muscle cells mediates immune complex deposition and superoxide generation.C1q与人类血管平滑肌细胞的结合介导免疫复合物沉积和超氧化物生成。
Inflammation. 1989 Oct;13(5):561-9. doi: 10.1007/BF00916762.
8
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