咖啡因和可可碱对产气荚膜梭菌肠毒素形成的刺激作用。
Stimulation of Clostridium perfringens enterotoxin formation by caffeine and theobromine.
作者信息
Labbe R G, Nolan L L
出版信息
Infect Immun. 1981 Oct;34(1):50-4. doi: 10.1128/iai.34.1.50-54.1981.
Abstract
In the presence of 100 micrograms of caffeine per ml or 200 micrograms of theobromine per ml, sporulation of Clostridium perfringens NCTC 8679 rose from less than 1 to 80 or 85%. Enterotoxin concentration increased from undetectable levels to 450 micrograms/mg of cell extract protein. Heat-resistant spore levels increased from less than 1,000 to between 1 X 10(7) and 2 X 10(7)/ml. These effects were partially reversible by the addition of adenosine or thymidine. In the case of NCTC 8238, caffeine and theobromine caused a three- to fourfold increase in the percentages of cells possessing refractile spores and a similar increase in enterotoxin concentration. Heat-resistant spore levels, however, were unaffected. Inosine was ineffective in promoting sporulation in NCTC 8679.
摘要
每毫升含有100微克咖啡因或每毫升含有200微克可可碱时，产气荚膜梭菌NCTC 8679的芽孢形成率从低于1%升至80%或85%。肠毒素浓度从检测不到的水平增至每毫克细胞提取物蛋白含450微克。耐热孢子水平从低于1000个/毫升增至1×10⁷至2×10⁷个/毫升。添加腺苷或胸苷后，这些效应部分可逆。就NCTC 8238而言，咖啡因和可可碱使具有折光性孢子的细胞百分比增加了三至四倍，肠毒素浓度也有类似增加。然而，耐热孢子水平未受影响。肌苷对促进NCTC 8679的芽孢形成无效。
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