Frink R J, Draper K G, Wagner E K
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6139-43. doi: 10.1073/pnas.78.10.6139.
The sequences of the DNAs encoding the 5' ends of one early and one late herpes simplex virus type 1 mRNA were analyzed, and the 5' ends of these mRNA species were precisely located. Neither mRNA species is spliced and the noncoding strand of the DNA contains recognizable T-A-T-A and C-A-T boxes upstream from their respective 5' ends. The early mRNA was efficiently transcribed by a commercially available uninfected cell lysate system, but the late mRNA was not. This difference between early and late mRNAs appears to be general in this virus.
对编码1型单纯疱疹病毒一种早期mRNA和一种晚期mRNA 5'端的DNA序列进行了分析，并精确确定了这些mRNA种类的5'端。这两种mRNA都不进行剪接，并且DNA的非编码链在其各自5'端上游含有可识别的T-A-T-A盒和C-A-T盒。早期mRNA能被市售的未感染细胞裂解物系统有效转录，但晚期mRNA则不能。早期和晚期mRNA之间的这种差异在该病毒中似乎是普遍存在的。
