Oehler J R, Lindsay L R, Nunn M E, Herberman R B
Int J Cancer. 1978 Feb 15;21(2):204-9. doi: 10.1002/ijc.2910210212.
Studies in mice and in humans have provided most of the available information concerning natural cell-mediated cytotoxicity. Rats represent a second experimental species which is well suited for the study of natural cytotoxicity. Our studies indicate that the distribution of natural killer (NK)3 cells in rat lymphoid tissues is similar to their tissue distribution in man, with high levels in the blood and spleen and low or undetectable levels in lymph node, thymus, thoracic duct or peritoneal exudate cells. The levels of NK activity varied considerably among various inbred strains of rats. However, the genetic control of levels of NK activity did not appear to be linked to the rat major histocompatibility complex. As recently demonstrated in mice by depletion experiments on antibody-erythrocyte monolayers, many or most rat natural killer cells were found to have surface receptors for the Fc portion of IgG.
对小鼠和人类的研究提供了有关天然细胞介导细胞毒性的大部分现有信息。大鼠是第二个非常适合用于天然细胞毒性研究的实验物种。我们的研究表明，大鼠淋巴组织中自然杀伤（NK）细胞的分布与其在人类组织中的分布相似，血液和脾脏中的水平较高，而淋巴结、胸腺、胸导管或腹腔渗出细胞中的水平较低或检测不到。不同近交系大鼠的NK活性水平差异很大。然而，NK活性水平的遗传控制似乎与大鼠主要组织相容性复合体无关。正如最近在小鼠中通过对抗体 - 红细胞单层的耗竭实验所证明的那样，发现许多或大多数大鼠自然杀伤细胞具有针对IgG Fc部分的表面受体。
