Denniston K J, Madden M J, Enquist L W, Vande Woude G
Gene. 1981 Dec;15(4):365-78. doi: 10.1016/0378-1119(81)90180-3.
We describe the characterization of 34 hybrid lambda bacteriophages carrying EcoRI fragments obtained from DNA of defective interfering particles of the Patton strain of Herpes simplex virus type 1 (HSV-1). All cloned fragments contained S region terminal repeat sequences (TRs) fused to unique HSV-1 DNA. Several fragments contained deletions and rearrangements not described previously for DNA of HSV-1 defective interfering particles. A model describing the generation of defective interfering DNA based on recombination events involving the terminal "a" sequence as presented.
我们描述了34种携带从单纯疱疹病毒1型（HSV-1）帕顿株缺陷干扰颗粒的DNA中获得的EcoRI片段的杂交λ噬菌体的特性。所有克隆片段都包含与独特的HSV-1 DNA融合的S区域末端重复序列（TRs）。几个片段包含以前未在HSV-1缺陷干扰颗粒的DNA中描述的缺失和重排。本文提出了一个基于涉及末端“a”序列的重组事件来描述缺陷干扰DNA产生的模型。
