Diamond L, Boyer D, O'Donnell M
Agents Actions. 1978 Oct;8(5):458-61. doi: 10.1007/BF02111428.
Intravenous administration of the benzothiazoline derivative tiaramide hydrochloride, to rats actively sensitized to ovalbumin, inhibited immunologic lung reactions in a dose-related manner. Methysergide also inhibited anaphylactic lung reactions. Serotonin, but not other chemical mediators, produced changes in pulmonary mechanics qualitatively similar to those produced by the sensitizing antigen. The bronchoconstrictive action of serotonin was blocked by methysergide and tiaramide. The latter drug also inhibited bronchoconstriction induced by methacholine. The results implicate serotonin as the primary mediator of the respiratory component of systemic anaphylaxis in the rat: however, the mechanism by which tiaramide inhibits anaphylactic bronchoconstriction remains to be elucidated.
给对卵清蛋白产生主动致敏的大鼠静脉注射苯并噻唑啉衍生物盐酸替拉米特，可呈剂量相关地抑制免疫性肺反应。麦角新碱也能抑制过敏性肺反应。5-羟色胺而非其他化学介质，能产生与致敏抗原所引起的肺力学变化在性质上相似的改变。5-羟色胺的支气管收缩作用被麦角新碱和替拉米特阻断。后一种药物还能抑制乙酰甲胆碱诱导的支气管收缩。这些结果表明5-羟色胺是大鼠全身性过敏反应中呼吸成分的主要介质：然而，替拉米特抑制过敏性支气管收缩的机制仍有待阐明。
