来自野生小鼠的一种高致癌性鼠白血病病毒的特性分析。
Characterization of a highly oncogenic murine leukemia virus from wild mice.
作者信息
Rasheed S, Pal B K, Gardner M B
出版信息
Int J Cancer. 1982 Mar 15;29(3):345-50. doi: 10.1002/ijc.2910290319.
We have isolated a highly lymphomagenic wild mouse virus by passage of a weakly oncogenic amphotropic murine leukaemia virus (MuLV-A) in NIH Swiss mice. This virus is similar in host range, interference and neutralization properties to that of the inoculated amphotropic virus but is distinct from it biochemically and causes lymphomas in 90-100% of mice within 1-2 months. Our results indicate that this highly oncogenic virus is a recombinant of wild mouse MuLV-A and sequences related to env gene region of the endogenous xenotropic virus of NIH Swiss mice.
我们通过将弱致癌性双嗜性鼠白血病病毒（MuLV-A）在NIH瑞士小鼠中传代，分离出了一种高度致淋巴瘤的野生小鼠病毒。这种病毒在宿主范围、干扰和中和特性方面与接种的双嗜性病毒相似，但在生化方面与之不同，并且在1-2个月内可使90-100%的小鼠发生淋巴瘤。我们的结果表明，这种高度致癌性病毒是野生小鼠MuLV-A与NIH瑞士小鼠内源性嗜异性病毒env基因区域相关序列的重组体。
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