Nomura A, Stemmermann G N, Wasnich R D
JAMA. 1982 Apr 23;247(16):2247-9.
In a study of 7,498 men of Japanese ancestry in Hawaii, 18 incident cases of primary hepatocellular carcinoma were identified after the follow-up period of 13 years. Sixteen of the 18 patients had stored serum specimens available for analysis. Ten of the 16 had positive serum test results for hepatitis B surface antigen in their original specimens. None of 48 matched controls subjects, whose stored serum specimens were also analyzed, had similar positive test results. This finding indicates that hepatitis B surface antigenemia preceded primary hepatocellular carcinoma in many patients.
在一项对夏威夷7498名日本裔男性的研究中，经过13年的随访期，共确诊了18例原发性肝细胞癌新发病例。18例患者中有16例留存有血清标本可供分析。这16例中的10例在其原始标本中乙肝表面抗原血清检测结果呈阳性。在同样对留存血清标本进行分析的48名匹配对照受试者中，无人有类似的阳性检测结果。这一发现表明，在许多患者中，乙肝表面抗原血症先于原发性肝细胞癌出现。
