Dal Canto M C, Rabinowitz S G
Ann Neurol. 1982 Feb;11(2):109-27. doi: 10.1002/ana.410110202.
One of the arguments in favor of a viral pathogenesis for multiple sclerosis is the existence of several experimental and natural animal models of virus-induced primary demyelination. This review deals comprehensively with such models. Well-known examples of demyelinating viral infections in their natural host are JHM, Theiler, visna, and canine distemper encephalomyelitides. Recent reports of experimental murine infections with pathogens such as vesicular stomatitis, Chandipura, herpes simplex, Venezuelan equine encephalomyelitis, and Semliki Forest viruses are also discussed. The thrust of the review is to include viral models suspected of producing primary demyelination on an immunopathological basis.
支持多发性硬化症病毒发病机制的一个论据是存在几种病毒诱导的原发性脱髓鞘的实验性和自然动物模型。本综述全面探讨了此类模型。在其自然宿主中脱髓鞘病毒感染的著名例子有JHM、泰勒氏病毒、维斯纳病毒和犬瘟热脑脊髓炎。还讨论了最近关于用诸如水泡性口炎病毒、钱迪普拉病毒、单纯疱疹病毒、委内瑞拉马脑炎病毒和Semliki森林病毒等病原体进行实验性小鼠感染的报告。综述的重点是纳入基于免疫病理学被怀疑产生原发性脱髓鞘的病毒模型。